Liquid ventilation.
Liquid ventilation.
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DOI：
10.4103/0259-1162.143109
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发表时间：
2014-09-01
期刊：
影响因子：
--
通讯作者：
Prakas, S
中科院分区：
文献类型：
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作者：
Sarkar, Suman;Paswan, Anil;Prakas, S
人类有肺来呼吸空气，他们没有鳃呼吸液体像鱼。当肺的气液界面的表面张力增加时，如急性肺损伤，科学家们开始考虑用液体代替空气填充肺，以降低表面张力并促进通气。液体通气（LV）是一种机械通气技术，其中肺部吹入含氧的全氟化学液体，而不是含氧气体混合物。使用全氟化合物而不是氮气作为氧气和二氧化碳的惰性载体为急性肺损伤的治疗提供了许多优势。此外，还有潜力不断扩大的非呼吸应用，包括肺部药物输送和放射成像。呼吸系统疾病是重症监护病房最常见的致病和致死原因之一。在过去几年中，已经采用了几种新的治疗方法。其中之一，可能是最迷人的，是LV。部分LV，其中大部分现有的研究已经集中，需要部分填充的肺与全氟化碳（PFC的）和通气与气体潮气量使用传统的机械呼吸机。PFC的各种物理化学性质使其成为理想的介质。它导致肺顺应性和氧合的显著改善以及平均气道压力和氧气需求的下降。未报告长期副作用。
Human have lungs to breathe air and they have no gills to breath liquids like fish. When the surface tension at the air-liquid interface of the lung increases as in acute lung injury, scientists started to think about filling the lung with fluid instead of air to reduce the surface tension and facilitate ventilation. Liquid ventilation (LV) is a technique of mechanical ventilation in which the lungs are insufflated with an oxygenated perfluorochemical liquid rather than an oxygen-containing gas mixture. The use of perfluorochemicals, rather than nitrogen as the inert carrier of oxygen and carbon dioxide offers a number of advantages for the treatment of acute lung injury. In addition, there are non-respiratory applications with expanding potential including pulmonary drug delivery and radiographic imaging. It is well-known that respiratory diseases are one of the most common causes of morbidity and mortality in intensive care unit. During the past few years several new modalities of treatment have been introduced. One of them and probably the most fascinating, is of LV. Partial LV, on which much of the existing research has concentrated, requires partial filling of lungs with perfluorocarbons (PFC's) and ventilation with gas tidal volumes using conventional mechanical ventilators. Various physico-chemical properties of PFC's make them the ideal media. It results in a dramatic improvement in lung compliance and oxygenation and decline in mean airway pressure and oxygen requirements. No long-term side-effect reported.