Concentration and composition of serum lipoproteins during a low-fat diet at two levels of polyunsaturated fat.
Concentration and composition of serum lipoproteins during a low-fat diet at two levels of polyunsaturated fat.
复制标题
两种多不饱和脂肪水平的低脂饮食期间血清脂蛋白的浓度和组成。
作者：
T. Kuusi;C. Ehnholm;J. Huttunen;E. Kostiainen;P. Pietinen;U. Leino;U. Uusitalo;T. Nikkari;J. Iacono;P. Puska
研究人员对来自芬兰北卡累利阿县的40个家庭进行了为期12周的饮食干预，该县的冠心病发病率和血清胆固醇值异常高。在12周的干预期间，所有家庭中来自脂肪的膳食能量比例从约39%降至23%。这些家庭被随机分为两组。20个家庭的饮食与多不饱和饱和脂肪（P/S）的比例为0.9（组I），而其他20个家庭的饮食与P/S的比例为0.4（组II）。血清总胆固醇分别下降了16%和9%的男性组I和II，并由16%的两组的女性。这些变化是由于低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇降低所致。LDL胆固醇和磷脂在两种干预饮食6周后达到最低值，但LDL蛋白反应较慢。因此，6周后，LDL的组成发生了变化，与基线饮食相比，胆固醇和磷脂减少，蛋白质和甘油三酯增加。在干预期间，血清胆固醇酯组分中的亚油酸含量增加，并且这种变化的幅度与总胆固醇和LDL胆固醇的变化呈负相关。两种干预饮食期间HDL胆固醇的降低是由于HDL 2胆固醇的下降（第I组和第II组中男性分别为29%和24%，女性分别为26%和25%）。（250字处删节）
A 12-week dietary intervention was carried out among 40 families from North Karelia, a county in Finland with an exceptionally high rate of coronary heart disease and high serum cholesterol values. The proportion of dietary energy derived from fat was reduced during the 12-week intervention period from about 39% to 23% in all families. The families were randomly allocated into two groups. Twenty families consumed a diet with a polyunsaturated to saturated fat (P/S) ratio of 0.9 (group I), while the other 20 families had a diet with a P/S ratio of 0.4 (group II). Total serum cholesterol decreased by 16% and 9% in men of groups I and II, respectively, and by 16% in women of both groups. These changes were due to a decrease in both low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol. LDL cholesterol and phospholipid reached minimum values after 6 weeks on both intervention diets, but LDL protein responded more slowly. Thus, after 6 weeks LDL had an altered composition containing less cholesterol and phospholipids and more protein and triglycerides than during the baseline diet. During the intervention, the linoleic acid content in the serum cholesteryl ester fraction increased, and the magnitude of this change correlated negatively with the changes in total and LDL cholesterol. The decrease in HDL cholesterol during the two intervention diets was due to a fall in the HDL2 cholesterol (29% and 24% in men, and 26% and 25% in women in groups I and II, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
血浆高密度脂蛋白胆固醇水平的流行病学。
影响因子：
37.8
作者：
Heiss,G;Johnson,NJ;Reiland,S;Davis,CE;Tyroler,HA
通讯作者：
Tyroler,HA
多不饱和脂肪对血浆脂蛋白和载脂蛋白组成的影响。
影响因子：
6.5
作者：
Vega,GL;Groszek,E;Wolf,R;Grundy,SM
通讯作者：
Grundy,SM