Stable vesicular nanoparticle 'Cerasome' as an organic-inorganic hybrid formed with organoalkoxysilane lipids having a hydrogen-bonding unit
Stable vesicular nanoparticle 'Cerasome' as an organic-inorganic hybrid formed with organoalkoxysilane lipids having a hydrogen-bonding unit
复制标题
DOI：
10.1016/s0040-6090(03)00745-4
复制
发表时间：
2003-08-22
期刊：
影响因子：
2.1
通讯作者：
Kikuchi, J
中科院分区：
文献类型：
--
作者：
Hashizume, M;Kawanami, S;Kikuchi, J
采用乙醇溶胶注入法，以具有氢键单元的双链有机烷氧基硅烷脂质体为原料，制备了表面覆盖陶瓷的脂质体膜--神经酰胺脂质体。通过扫描和透射电子显微镜、光散射和差示扫描量热法等多种物理测量手段对由此制备的神经酰胺脂质体进行表征。与用具有季铵头部代替无机部分的脂质形成的脂质体相比，神经酰胺脂质体更稳定，即使在过量的表面活性剂存在下也能保持其囊泡结构，其中常规脂质体完全溶解。讨论了Cerasome作为有机-无机杂化材料用于纳米器件制造的潜力。(C)2003 Elsevier Science B. V.保留所有权利。
Cerasomes, liposomal membranes covered with ceramic surface, were prepared from double-chain organoalkoxysilane lipids with a hydrogen-bonding unit by using ethanol sol injection method. The Cerasomes thus prepared were characterized by means of various physical measurements such as scanning and transmission electron microscopy, light scattering and differential scanning calorimetry. As compared with liposomes formed with a lipid having a quaternary ammonium head in place of the inorganic moiety, the Cerasomes were more stable to maintain their vesicular structures even in the presence of excessive amounts of a surfactant, in which the conventional liposomes were completely dissolved. Potential of the Cerasome as an organic-inorganic hybrid material for nano-device fabrications were discussed. (C) 2003 Elsevier Science B.V. All rights reserved.