EVOLUTION OF CATALYTIC PROTEINS OR ON THE ORIGIN OF ENZYME SPECIES BY MEANS OF NATURAL-SELECTION
EVOLUTION OF CATALYTIC PROTEINS OR ON THE ORIGIN OF ENZYME SPECIES BY MEANS OF NATURAL-SELECTION
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DOI：
10.1007/bf02101984
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发表时间：
1984-01-01
影响因子：
3.9
通讯作者：
BEEBY, R
中科院分区：
文献类型：
--
作者：
KACSER, H;BEEBY, R
所有现代生物体都可能是从一个共同的细胞祖先传下来的。这样的细胞一定是从更原始、更简单的前体进化而来的，但它们的组织和进化途径都不是今天可用的分子技术所能达到的。根据酶的功能特性和生长动力学，提出了一种机制，以重建早期酶进化的一般过程。一个前体细胞含有非常少的多功能酶与低催化活性，不可避免地导致后代与大量的分化单功能酶与高营业额数字。突变和自然选择更快的增长被证明是唯一必要的条件，这样的变化已经发生。
All present-day organisms presumably descended from a common cellular ancestor. Such a cell must have evolved from more primitive and simpler precursors, but neither their organization nor the route such evolution took are accessible to the molecular techniques available today. A mechanism is proposed, based on functional properties of enzymes and the kinetics of growth, to reconstruct the general course of early enzyme evolution. A precursor cell containing very few multifunctional enzymes with low catalytic activities is shown to lead inevitably to descendants with a large number of differentiated monofunctional enyzmes with high turnover numbers. Mutation and natural selection for faster growth are shown to be the only conditions necessary for such a change to have occurred.