Pediatric Neurodevelopmental Delays in Children 0 to 5 Years of Age With Sickle Cell Disease: A Systematic Literature Review.
Pediatric Neurodevelopmental Delays in Children 0 to 5 Years of Age With Sickle Cell Disease: A Systematic Literature Review.
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DOI：
10.1097/mph.0000000000002091
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发表时间：
2021-04-01
期刊：
影响因子：
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通讯作者：
Tanabe P
中科院分区：
文献类型：
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作者：
Knight LMJ;King AA;Strouse JJ;Tanabe P
镰状细胞病（SCD）是最常见的异常遗传性血液病，影响约10万美国人。大约20%至37%的镰状细胞贫血儿童在14岁时发生无症状脑梗死。神经认知缺陷在患有SCD的婴儿和学龄前儿童中被确定。本系统性文献综述的目的是全面了解5岁及以下SCD儿童神经发育迟缓（NDD）的患病率、严重程度和相关风险因素。系统检索6个数据库，识别出2467篇潜在相关出版物，通过手动检索识别出8篇。只有24篇文章符合纳入标准。我们发现NDD（认知、运动或两者）的患病率增加。儿童在语言、注意力和行为、执行功能、入学准备和/或学习成绩以及运动技能（精细和粗大运动功能）方面存在缺陷。风险因素包括无症状性脑梗死和中风、SCD基因型（HbSS > HbSC）、其他生物学和社会因素。NDD在0至5岁的SCD儿童中很常见。这是一个机会，以提高遵守国家指南的建议和早期发现的做法，儿科医生，血液学家和其他卫生保健提供者。
Sickle cell disease (SCD) is the most common abnormal genetic blood disease that affects ~100,000 Americans. Approximately 20% to 37% of children with sickle cell anemia have silent cerebral infarcts by the age of 14 years old. Neurocognitive deficits are identified in infants and preschool children with SCD. The purpose of this systematic literature review is to provide a comprehensive understanding of the prevalence, severity, and the associated risk factors for neurodevelopmental delays (NDDs) in children with SCD 5 years of age and younger. Systematic search of 6 databases identified 2467 potentially relevant publications and 8 were identified through a manual search. Only 24 articles met the inclusion criteria. We identified an increased prevalence of NDDs (cognitive, motor, or both). Children experienced deficits with language, attention and behavior, executive functioning, school readiness and/or academic performance, and motor skills (fine and gross motor functioning). Risk factors include silent cerebral infarcts and strokes, SCD genotype (HbSS > HbSC), other biologic, and social factors. NDDs are common in children ages 0 to 5 years old with SCD. There is an opportunity to improve adherence to national guideline recommendations and early detection practices by pediatricians, hematologists, and other health care providers.