Depression as a potential causal factor in subsequent miscarriage in recurrent spontaneous aborters
Depression as a potential causal factor in subsequent miscarriage in recurrent spontaneous aborters
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DOI：
10.1093/humrep/17.10.2580
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发表时间：
2002-10-01
影响因子：
6.1
通讯作者：
Kitamura, T
中科院分区：
文献类型：
--
作者：
Sugiura-Ogasawara, M;Furukawa, T;Kitamura, T
背景技术背景：不明原因的流产被推测是由于Th 1/Th 2细胞因子在胎儿-母体界面的不平衡和免疫功能是已知的各种心理因素的影响下。事实上，心理-神经-免疫-内分泌网络被认为是导致流产的原因。为了评估心理障碍是否可能导致自然流产，我们进行了一项前瞻性研究，以确定是否有任何心理参数影响复发性流产史患者的风险。方法：对61例有两次连续早期妊娠流产史的患者进行了前瞻性研究。一组自我报告的问卷调查，包括症状自评量表-90修订版和NEO五因素指数和半结构化访谈进行了后续怀孕前。我们调查了这些参数是否可以预测随后的流产。结果：45例患者中有10例（22.2%）再次流产。基线抑郁症状影响随后的流产（P = 0.004），当我们用Bonferoni校正时，这种统计学显著影响仍然存在（P = 0.036）。结论：在反复流产的患者中，高抑郁量表与高流产率相关。
BACKGROUND: Unexplained miscarriage is speculated to be due to a Th1/Th2 cytokine imbalance at the feto-maternal interface and immunological functions are known to be under the influence of various psychological factors. Indeed, the psycho-neuro-immuno-endocrine network has been proposed to contribute to miscarriage. To assess whether psychological disorders might induce spontaneous abortion we carried out a prospective study to determine if any psychological parameter influenced risk in those patients with a history of recurrent miscarriages. METHODS: A prospective study was carried out on 61 patients with a history of two consecutive first-trimester miscarriages. A battery of self-report questionnaires including Symptom Checklist-90 Revised and the NEO Five Factor Index and semi-structured interviews were conducted before a subsequent pregnancy. We investigated whether or not these parameters predicted subsequent miscarriages. RESULTS: Ten (22.2%) of the 45 patients who conceived miscarried again. Baseline depressive symptoms influenced subsequent miscarriage (P = 0.004) This statistically significant effect remained when we corrected with Bonfferoni adjustment (P = 0.036). CONCLUSIONS: A high depression scale is associated with a high miscarriage rate, in those patients suffering recurrent miscarriage.