Efficacy-based identification of active component of hachimijiogan ameliorating diabetic nephropathy.
Efficacy-based identification of active component of hachimijiogan ameliorating diabetic nephropathy.
复制标题
基于功效的八味姜丸改善糖尿病肾病活性成分的鉴定。
DOI：
10.11339/jtm.26.221
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
C. Park
中科院分区：
文献类型：
--
作者：
T. Yokozawa;N. Yamabe;K. Kang;C. Park
传统药物，包括中药，由于其广泛而独特的生物活性而没有毒副作用而备受关注。我们利用1型糖尿病肾病大鼠肾大部切除加链脲佐菌素注射模型和大冢龙-埃文德岛肥胖大鼠作为人类2型糖尿病及其并发症模型，评估了八目健肝的作用，并鉴定了其活性化合物改善糖尿病肾损害的作用。八目参肝治疗降低了葡萄糖诱导的氧化应激、晚期糖基化终产物形成、肾蛋白过表达和蛋白尿的水平。这些结果表明八目健肝是治疗1型和2型糖尿病肾病的潜在药物。此外，根据山茱萸的活性成分鉴定，7- o -没食子酰- d -sedoheptulose被认为是预防和/或延缓糖尿病肾损害发生的最重要的因素。7- o -没食子酰- d -sedoheptulose有望为糖尿病肾病的发展提供一种新的治疗策略。
Traditional medicines, including Chinese prescriptions, have attracted much attention due to their extensive and unique biological activities without toxic and/or side effects. We evaluated the effects of hachimijiogan and identified its active compound ameliorating diabetic renal damage using a type 1 diabetic nephropathy rat model which underwent a subtotal nephrectomy plus streptozotocin injection, and Otsuka Long-Evans Tokushima Fatty rats as a model of human type 2 diabetes and its complications. Hachimijiogan treatment decreased the levels of glucose-induced oxidative stress, advanced glycation endproduct formation, renal protein overexpression, and proteinuria. These results indicate that hachimijiogan is a potential therapeutic agent in the development of type 1 and 2 diabetic nephropathy. Furthermore, according to the identification of the active component of the crude drug, Corni Fructus, 7-O-galloyl-D-sedoheptulose is considered to be the most important contributor to prevent and/or delay the onset of diabetic renal damage. 7-O-Galloyl-D-sedoheptulose is expected to provide a novel therapeutic strategy against the development of diabetic nephropathy.