Fluctuations in pO2 in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy
Fluctuations in pO2 in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy
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DOI：
10.1016/j.radonc.2005.09.009
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发表时间：
2005-11-01
影响因子：
5.7
通讯作者：
Rofstad, EK
中科院分区：
文献类型：
--
作者：
Brurberg, KG;Skogmo, HK;Rofstad, EK
背景和目的：肿瘤组织中氧分压（pO（2））的空间异质性已被广泛研究，然而，关于时间异质性的信息很少。本研究的目的是寻找未经治疗和放射治疗的自发性犬肿瘤中pO（2）的波动，并调查肿瘤的总体氧合状态和pO（2）波动模式之间是否存在关系。对原发性肿瘤进行18次3戈伊剂量的照射。Eppendorf极谱电极和OxyLite荧光探针分别用于测量总体氧合状态和pO（2）波动模式。在治疗前3天以及放射分次4、7和10前即刻记录组织pO（2）。结果：肿瘤的总体氧合状态差异显著。放射治疗对总体氧合状态没有一致的影响。波动pO（2）中检测到未经处理以及照射的肿瘤，和独立的肿瘤是否是不良或良好oxygenated.Conclusions：波动pO（2）可以发生在未经处理和照射的自发犬肿瘤。pO（2）波动模式与总体肿瘤氧合状态之间无相关性。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Background and purpose: The spatial heterogeneity in oxygen tension (pO(2)) in tumor tissue has been studied extensively, whereas, the information about the temporal heterogeneity is sparse. The purpose of the present study was to search for pO(2) fluctuations in untreated and irradiated spontaneous canine tumors, and to investigate whether there is a relationship between overall tumor oxygenation status and pO(2) fluctuation pattern.Patients and methods: Six dogs scheduled for radiation therapy of head and neck cancer were included in the study. The primary tumors were irradiated with 18 fractions of 3 Gy. Eppendorf polarographic electrodes and OxyLite fluorescence probes were used to measure overall oxygenation status and pO(2) fluctuation pattern, respectively. Tissue pO(2) was recorded at three subsequent days prior to treatment, and immediately before radiation fraction 4, 7, and 10.Results: Overall oxygenation status differed substantially among the tumors. Radiation therapy had no consistent effect on overall oxygenation status. Fluctuations in pO(2) were detected in untreated as well as irradiated tumors, and independent of whether the tumors were poorly or well oxygenated.Conclusions: Fluctuations in pO(2) can occur in untreated and irradiated spontaneous canine tumors. There is no correlation between pO(2) fluctuation pattern and overall tumor oxygenation status. (c) 2005 Elsevier Ireland Ltd. All rights reserved.