Pubertal Suppression for Transgender Youth and Risk of Suicidal Ideation
Pubertal Suppression for Transgender Youth and Risk of Suicidal Ideation
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DOI：
10.1542/peds.2019-1725
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发表时间：
2020-02-01
期刊：
影响因子：
8
通讯作者：
Keuroghlian, Alex S.
中科院分区：
文献类型：
--
作者：
Turban, Jack L.;King, Dana;Keuroghlian, Alex S.
背景和目的：促性腺激素释放激素类似物通常用于抑制变性青少年的内源性青春期。关于这种治疗的心理健康益处的数据有限。我们这项研究的目的是检查青春期抑制与成人心理健康结果之间的关系。方法：我们对20619名18至36岁的跨性别成年人进行了横断面调查，研究了青春期自我报告的青春期抑制史。使用多变量逻辑回归，我们研究了青春期抑制和成年心理健康结果之间的关系，包括自杀倾向的多个指标。结果：在样本中，16.9%的人报告说，他们曾经希望青春期抑制作为他们的性别相关护理的一部分。他们的平均年龄为23.4岁，45.2%在出生时被指定为男性。其中，2.5%的人接受了青春期抑制。在调整人口统计学变量和性别认同的家庭支持水平后，与那些希望青春期抑制但没有接受青春期抑制治疗的人相比，接受青春期抑制治疗的人终生自杀意念的几率较低（调整后的比值比= 0.3; 95%置信区间= 0.2-0.6）。结论：这是第一个研究青春期抑制和自杀之间的联系。有一个显着的负相关性治疗青春期抑制在青春期和终身自杀意念的变性成年人谁曾经想要这种治疗。这些结果与过去的文献一致，表明想要这种治疗的跨性别青少年的青春期抑制与良好的心理健康结果相关。根据对年轻跨性别成年人的大型横断面调查，青春期获得青春期抑制与终生自杀意念的几率较低相关。
BACKGROUND AND OBJECTIVES: Gonadotropin-releasing hormone analogues are commonly prescribed to suppress endogenous puberty for transgender adolescents. There are limited data regarding the mental health benefits of this treatment. Our objective for this study was to examine associations between access to pubertal suppression during adolescence and adult mental health outcomes. METHODS: Using a cross-sectional survey of 20 619 transgender adults aged 18 to 36 years, we examined self-reported history of pubertal suppression during adolescence. Using multivariable logistic regression, we examined associations between access to pubertal suppression and adult mental health outcomes, including multiple measures of suicidality. RESULTS: Of the sample, 16.9% reported that they ever wanted pubertal suppression as part of their gender-related care. Their mean age was 23.4 years, and 45.2% were assigned male sex at birth. Of them, 2.5% received pubertal suppression. After adjustment for demographic variables and level of family support for gender identity, those who received treatment with pubertal suppression, when compared with those who wanted pubertal suppression but did not receive it, had lower odds of lifetime suicidal ideation (adjusted odds ratio = 0.3; 95% confidence interval = 0.2-0.6). CONCLUSIONS: This is the first study in which associations between access to pubertal suppression and suicidality are examined. There is a significant inverse association between treatment with pubertal suppression during adolescence and lifetime suicidal ideation among transgender adults who ever wanted this treatment. These results align with past literature, suggesting that pubertal suppression for transgender adolescents who want this treatment is associated with favorable mental health outcomes.According to a large cross-sectional survey of young transgender adults, access to pubertal suppression during adolescence is associated with lower odds of lifetime suicidal ideation.