Premature mortality in autism spectrum disorder
Premature mortality in autism spectrum disorder
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DOI：
10.1192/bjp.bp.114.160192
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发表时间：
2016-03-01
影响因子：
10.5
通讯作者：
Bolte, Sven
中科院分区：
文献类型：
--
作者：
Hirvikoski, Tatja;Mittendorfer-Rutz, Ellenor;Bolte, Sven
研究背景孤独症谱系障碍（ASD）的死亡率被认为是增加的，目的研究ASD的全因和病因特异性死亡率，以及性别和智力的调节作用。（n = 27122，1987年至2009年期间确诊）与性别、年龄和居住地匹配的对照组相比结果观察期内，24358例患者中，一般人群中有0.91%的人死亡，而ASD患者的相应数字为706（2.60%; OR = 2.56; 95%CI 2.38-2.76）。病因特异性分析显示，几乎所有分析的诊断类别的ASD死亡率升高。死亡率和模式的原因特异性死亡率部分缓和的性别和一般的智力ability.ConclusionsPremature死亡率显着增加ASD由于众多的医疗条件。
BackgroundMortality has been suggested to be increased in autism spectrum disorder (ASD).AimsTo examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability.MethodOdds ratios (ORs) were calculated for a population-based cohort of ASD probands (n = 27 122, diagnosed between 1987 and 2009) compared with gender-, age-and county of residence-matched controls (n = 2 672 185).ResultsDuring the observed period, 24 358 (0.91%) individuals in the general population died, whereas the corresponding figure for individuals with ASD was 706 (2.60%; OR = 2.56; 95% CI 2.38-2.76). Cause-specific analyses showed elevated mortality in ASD for almost all analysed diagnostic categories. Mortality and patterns for cause-specific mortality were partly moderated by gender and general intellectual ability.ConclusionsPremature mortality was markedly increased in ASD owing to a multitude of medical conditions.