Exposure to low dose ionising radiation: Molecular and clinical consequences.
Exposure to low dose ionising radiation: Molecular and clinical consequences.
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DOI：
10.1016/j.canlet.2013.12.015
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发表时间：
2014
期刊：
影响因子：
9.7
通讯作者：
Lynn M. Martin;B. Marples;T. Lynch;D. Hollywood;L. Marignol
中科院分区：
文献类型：
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作者：
Lynn M. Martin;B. Marples;T. Lynch;D. Hollywood;L. Marignol
本文对低剂量高放射敏感性(HRS)的发生率、机制和意义的实验数据进行了全面的综述。从过去和现在的研究中获得的重要发现被绘制并突出显示，以说明我们目前对HRS的理解的途径，以及HRS对哺乳动物细胞对辐射的反应的影响。特别注意的是表明DNA修复过程在反应中发挥作用的证据，表明细胞周期检查点过程作用的证据，以及调查该效应的临床含义/相关性的证据。
This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.