Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein?
Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein?
复制标题
蛋白质合成抑制剂、基因超诱导和记忆：蛋白质太少或太多？
DOI：
10.1016/j.nlm.2007.08.008
复制
发表时间：
2008
影响因子：
2.7
通讯作者：
Tronson,NatalieC
中科院分区：
文献类型：
--
作者：
Radulovic,Jelena;Tronson,NatalieC
To date, the effects of protein synthesis inhibitors (PSI) in learning and memory processes have been attributed to translational arrest and consequent inhibition of de novo protein synthesis. Here we argue that amnesia produced by PSI can be the direct result of their abnormal induction of mRNA—a process termed gene superinduction. This action exerted by PSI involves an abundant and prolonged accumulation of mRNA transcripts of genes that are normally transiently induced. We summarize experimental evidence for the multiple mechanisms and signaling pathways mediating gene superinduction and consider its relevance for PSI-induced amnesia. This mechanistic alternative to protein synthesis inhibition is compared to models of electroconvulsive seizures and fragile×syndrome associated with enhanced mRNA/protein levels and cognitive deficits.
