Neural correlates of attention and working memory deficits in HIV patients
Neural correlates of attention and working memory deficits in HIV patients
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DOI：
10.1212/wnl.57.6.1001
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发表时间：
2001-09-25
期刊：
影响因子：
9.9
通讯作者：
Ernst, T
中科院分区：
文献类型：
--
作者：
Chang, L;Speck, O;Ernst, T
目的：探讨HIV-1感染者注意和工作记忆障碍的神经相关性。方法：fMRI用于评估11名HIV患者和11名年龄，性别，教育和惯用手匹配的血清阴性受试者的大脑活动，同时执行一系列需要不同注意力水平的工作记忆任务。结果如下：与对照组相比，HIV患者在执行相同任务时在某些区域表现出更大的大脑激活（血氧水平依赖性信号变化）。对于较简单的任务，HIV患者在顶叶区域表现出更大的激活。然而，在更困难的任务中，HIV患者的额叶表现出更大的激活。在这些任务的反应时间较慢，但准确性是相似的艾滋病毒患者与对照组相比。结论：HIV感染对神经基质造成的损伤可能需要对神经回路进行更大的注意力调节，因此需要更多地使用大脑储备;需要额叶的额外激活来执行更复杂的任务。HIV患者的任务依赖性额叶激活增加表明，注意力缺陷的神经相关性可能是额纹状体脑损伤导致的过度注意力调节。
Objectives: To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1. Method: fMRI was used to evaluate brain activity in 11 patients with HIV and 11 age-, sex-, education-, and handedness-matched seronegative subjects, while performing a battery of tasks that required different levels of attention for working memory. Results: Patients with HIV showed greater brain activation (blood oxygenation level dependent signal changes) in some regions compared with control subjects while performing the same tasks. For the simpler tasks, patients with HIV showed greater activation in the parietal regions. However, with more difficult tasks, patients with HIV showed greater activation additionally in the frontal lobes. Reaction times during these tasks were slower but accuracy was similar in the patients with HIV compared with control subjects. Conclusion: Injury to the neural substrate caused by HIV infection may necessitate greater attentional modulation of the neural circuits, hence a greater use of the brain reserve; additional activation of the frontal lobes is required to perform the more complex tasks. The task-dependent increased frontal activation in patients with HIV suggests that the neural correlate of attentional deficits may be excessive attentional modulation as a result of frontostriatal brain injury.