The dopamine D1 receptor is involved in the regulation of REM sleep in the rat.
The dopamine D1 receptor is involved in the regulation of REM sleep in the rat.
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DOI：
10.1016/0014-2999(91)90104-x
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发表时间：
1991-03
影响因子：
5
通讯作者：
M. Trampus;N. Ferri;A. Monopoli;E. Ongini
中科院分区：
文献类型：
--
作者：
M. Trampus;N. Ferri;A. Monopoli;E. Ongini
The dopamine D1receptor agonist, SKF 38393, and the D1antagonist, SCH 23390, were studied for their effects on sleep in the rat. Over 6 h, SKF 38393 (0.1–10 mg/kg s.c.) dose dependently reduced the amount of rapid eye movement (REM) sleep and enhanced the duration of wakefulness. The drug affected REM at low doses (ED50= 0.4 mg/kg) at which wakefulness was unchanged and the characteristic grooming behavior was not apparent. REM changes were characterized by a decrease in the number of episodes with no alteration of latency to the first episode. Over a very low dose range (0.003–0.3 mg/kg s.c.), SCH 23390 enhanced the amount of REM by increasing both number and average duration of episodes. There was also a moderate increase of non-REM sleep but the percent change was less marked than that occurring for REM. Given at 0.003 mg/kg, SCH 23390 prevented the REM changes induced by SKF 38393 (0.3–3 mg/kg). It is suggested that D1receptors are involved in the regulation of the REM sleep process.
