Chemiluminescence from an erythrocyte folic acid oxidase from normal individuals and from cancer patients.
Chemiluminescence from an erythrocyte folic acid oxidase from normal individuals and from cancer patients.
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来自正常个体和癌症患者的红细胞叶酸氧化酶的化学发光。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
J. Diaz
中科院分区：
文献类型：
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作者：
N. Durán;G. Gisler;J. Diaz
Folic acid oxidase from erythrocytes oxidatively cleaves folic acid at the C-9-N-10 bond to yield pterin-6-aldehyde and p-aminobenzoyl glutamic acid, with the concomitant generation of singlet oxygen. The emission from singlet oxygen is proportional to the enzyme activity. DABCO was used as a singlet oxygen emission enhancer to increase the sensitivity of the measurement. In general, pregnant women show high enzymatic activity, but the emission is strongly quenched by DABCO. This is contrary to normal and cancer cases in which an increase in the emission was observed. This effect is larger in cancer cases. These results are presented as a potential method for detecting physiological and pathological human conditions.
