Improved iron status parameters may be a benefit of hormone replacement therapy.
Improved iron status parameters may be a benefit of hormone replacement therapy.
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改善铁状态参数可能是激素替代疗法的一个好处。
DOI：
10.1089/152460900318632
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Schwertz,D
中科院分区：
文献类型：
--
作者：
Penckofer,S;Schwertz,D
激素替代疗法（HRT）的好处之一是减少心血管疾病。HRT可能在降低心血管风险中发挥作用的机制是通过改善铁状态参数。 高血清铁蛋白与冠心病风险增加有关，而低铁结合力已被确定为心肌梗死的重要危险因素。本研究 对一组口服HRT的绝经后妇女（n= 27）和未口服HRT的绝经后妇女（n= 27）进行了两次间隔1年的铁状态参数检查。女性在以下方面进行了比较 血清测量：雌二醇、脂质、铁、总铁结合力和铁蛋白。接受HRT的妇女雌二醇水平较高（p< 0.001），血脂水平改善（p< 0.001）。 （总胆固醇和低密度脂蛋白胆固醇较低，高密度脂蛋白胆固醇水平较高）。此外，接受HRT的女性比未接受HRT的女性具有更好的铁状态参数 HRT（p= 0.002）。总铁结合力是更大的妇女HRT比妇女没有HRT，血清铁蛋白水平较低的妇女HRT比那些没有HRT。各组 年龄、体重指数和体力活动相当。我们的研究结果证实了以前的研究结果，并指出，妇女采取HRT有较高的血清雌二醇水平和改善血脂谱相比， 与那些没有服用激素替代疗法的人此外，我们还发现，接受HRT的女性体内的铁状态参数更好，这表明需要进一步研究这种影响，因为它与降低心血管疾病的发生有关。 绝经后妇女的风险。
One of the benefits of hormone replacement therapy (HRT) is to decrease cardiovascular disease. A mechanism whereby HRT may play a role in reducing cardiovascular risk is through improved iron status parameters. High serum ferritin has been related to increased risk of coronary heart disease, whereas low iron-binding capacity has been identified as an important risk factor for myocardial infarction. This study examined iron status parameters in a group of postmenopausal women taking oral HRT (n= 27) and those not taking oral HRT (n= 27) at two times 1 year apart. Women were compared on the following serum measures: estradiol, lipids, iron, total iron-binding capacity, and ferritin. Women taking HRT had higher levels of estradiol (p< 0.001) and improved lipid profiles (p< 0.001) (lower total and lowdensity lipoprotein [LDL] cholesterol and higher levels of high-density lipoprotein [HDL] cholesterol). In addition, women on HRT had better iron status parameters than those not on HRT (p= 0.002). Total iron-binding capacity was greater for women on HRT compared with women not on HRT, and serum ferritin levels were lower in women on HRT than those not on HRT. The groups were comparable in age, body mass index, and physical activity. Our results confirm previous findings and indicate that women taking HRT have higher serum levels of estradiol and improved lipid profiles compared with those not taking HRT. In addition, we have found that iron status parameters are better in women taking HRT, suggesting the need to further examine this effect as it relates to decreased cardiovascular risk in postmenopausal women.