Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.
Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.
复制标题
脱氧尿苷的硫汞类似物在体外抑制单纯疱疹病毒 1 型和 2 型复制。
DOI：
10.1016/0166-3542(91)90025-m
复制
发表时间：
1991
影响因子：
7.6
通讯作者：
Williams,MV
中科院分区：
文献类型：
--
作者：
Holliday,J;Williams,MV
研究了几种2 ' -脱氧尿苷（dUrd） 5-汞基类似物对1型单纯疱疹病毒（HSV-1）和2型单纯疱疹病毒（HSV-2）的体外抗病毒活性。在这些化合物中，5-汞-2 ' -脱氧尿苷（HgdUrd）的硫甘油酯类似物对HSV-1在KB细胞中的复制最有效，其50%抑制剂量（ID50）为0.001 μg/ml，而HgdUrd的谷胱甘肽类似物对HSV-2的复制最有效，ID50为0.075 μg/ml。相反，在HeLa TK−细胞中，HgdUrd的巯基鸟苷类似物是抑制病毒复制最有效的化合物，对HSV-1和HSV-2的id50分别为0.098和0.001 μg/ml。这些结果表明，这些dUrd的汞基类似物与无环鸟苷一样有效地阻止这些疱疹病毒的复制。
The in vitro antiviral activity of several 5-mercurithio analogs of 2′-deoxyuridine (dUrd) on the replication of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) were examined. Of those compounds tested, the thioglycerol analog of 5-mercuri-2′-deoxyuridine (HgdUrd) was most effective in inhibiting the replication of HSV-1 in KB cells with a 50% inhibitory dose (ID50) of 0.001 μg/ml while the glutathione analog of HgdUrd was the most effective in inhibiting the replication of HSV-2 with a ID50of 0.075 μg/ml. Conversely in HeLa TK−cells, the mercaptoguanosine analog of HgdUrd was the most effective compound in inhibiting virus replication with ID50s of 0.098 and 0.001 μg/ml for HSV-1 and HSV-2 respectively. These results suggest that these mercurithio analogs of dUrd are as effective as acyclovir in preventing the replication of these herpesviruses.