Current Knowledge on Contralateral Prophylactic Mastectomy Among Women with Sporadic Breast Cancer
Current Knowledge on Contralateral Prophylactic Mastectomy Among Women with Sporadic Breast Cancer
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DOI：
10.1634/theoncologist.2011-0022
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发表时间：
2011-07-01
期刊：
影响因子：
5.8
通讯作者：
Parker, Patricia A.
中科院分区：
文献类型：
--
作者：
Brewster, Abenaa M.;Parker, Patricia A.
从 1993 年到 2003 年，美国单侧浸润性乳腺癌患者中使用对侧预防性乳房切除术 (CPM) 的人数增加了 150%。虽然 CPM 已被证明可以降低患对侧乳腺癌的风险，但关于它是否能降低乳腺癌死亡率或总死亡率，存在相互矛盾的证据。 CPM 率的增加在患有早期散发性乳腺癌的女性中尤其令人担忧，这些女性每年患对侧乳腺癌的风险极小，而且对于其中许多女性来说，远处转移性疾病的风险超过了对侧乳腺癌的风险。缺乏关于 CPM 对散发性乳腺癌女性的临床价值的信息是一个重要的公共卫生问题。本综述评估了 CPM 临床适应症以及长期患者满意度和心理社会结果的当前数据。关于 CPM 临床价值的认识存在差距，包括影响散发性乳腺癌女性 CPM 决策过程的患者和医生相关社会心理因素。肿瘤学家 2011；16：935-941
The use of contralateral prophylactic mastectomy (CPM) in the U. S. among patients with unilateral invasive breast cancer increased by 150% from 1993 to 2003. Although CPM has been shown to reduce the risk for developing contralateral breast cancer, there is conflicting evidence on whether or not it reduces breast cancer mortality or overall death. The increase in the CPM rate is especially concerning among women with early-stage sporadic breast cancer who have a minimal annual risk for developing contralateral breast cancer, and for many of these women the risk for distant meta-static disease outweighs the risk for contralateral breast cancer. The lack of information about the clinical value of CPM in women with sporadic breast cancer is an important public health problem. This review evaluates current data on the clinical indications for CPM and long-term patient satisfaction and psychosocial outcomes. Gaps in knowledge about the clinical value of CPM, including patient- and physician-related psychosocial factors that influence the decision-making process of CPM among women with sporadic breast cancer, are highlighted. The Oncologist 2011;16:935-941