Protection in Animal Models of Brain and Spinal Cord Injury with Mild to Moderate Hypothermia
Protection in Animal Models of Brain and Spinal Cord Injury with Mild to Moderate Hypothermia
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DOI：
10.1089/neu.2008.0806
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发表时间：
2009-03-01
影响因子：
4.2
通讯作者：
Bramlett, Helen M.
中科院分区：
文献类型：
--
作者：
Dietrich, W. Dalton;Atkins, Coleen M.;Bramlett, Helen M.
在过去的20年里，世界各地的各种实验室已经表明，轻度至中度的低温导致脑和脊髓损伤（SCI）的各种模型的神经保护和改善的功能结果。虽然深低温在中枢神经系统（CNS）损伤期间和之后的潜在神经保护作用早已被认识到，但最近的研究已经描述了在各种CNS损伤之后使用低温保护脑和脊髓的临床可行策略。在某些情况下，只有一个或两个度的脑或核心温度下降可以有效地保护中枢神经系统免受损伤。或者，在各种损伤模型中，将大脑温度仅升高正常体温水平几度会导致后果。基于这些数据，在实验和临床环境中，治疗性低温的潜在用途已经出现复苏。治疗性低温的研究现在是一个国际性的调查领域，来自世界各地的科学家和临床医生为这一重要的、有前途的治疗干预做出了贡献。本文综述了在脑和脊髓损伤动物模型中获得的实验数据，证明了轻度至中度低温的益处。这些研究为将该疗法转化为临床竞技场提供了关键数据。亚低温的有益作用的机制进行了总结。
For the past 20 years, various laboratories throughout the world have shown that mild to moderate levels of hypothermia lead to neuroprotection and improved functional outcome in various models of brain and spinal cord injury (SCI). Although the potential neuroprotective effects of profound hypothermia during and following central nervous system (CNS) injury have long been recognized, more recent studies have described clinically feasible strategies for protecting the brain and spinal cord using hypothermia following a variety of CNS insults. In some cases, only a one or two degree decrease in brain or core temperature can be effective in protecting the CNS from injury. Alternatively, raising brain temperature only a couple of degrees above normothermia levels worsens outcome in a variety of injury models. Based on these data, resurgence has occurred in the potential use of therapeutic hypothermia in experimental and clinical settings. The study of therapeutic hypothermia is now an international area of investigation with scientists and clinicians from every part of the world contributing to this important, promising therapeutic intervention. This paper reviews the experimental data obtained in animal models of brain and SCI demonstrating the benefits of mild to moderate hypothermia. These studies have provided critical data for the translation of this therapy to the clinical arena. The mechanisms underlying the beneficial effects of mild hypothermia are also summarized.