Multivariate analysis of temporal descriptions of open-field behavior in wild-derived mouse strains
Multivariate analysis of temporal descriptions of open-field behavior in wild-derived mouse strains
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DOI：
10.1007/s10519-005-9038-3
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发表时间：
2006-09-01
影响因子：
2.6
通讯作者：
Koide, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Takahashi, Aki;Kato, Katsunori;Koide, Tsuyoshi
旷场试验是许多行为学研究中常用的仪器。然而，在大多数研究中，行为细节的时间变化被忽略了。因此，我们研究了开放领域的行为，测量传统的指数和12 ethograms支持详细的时间观察。为了获得更广泛的理解，我们使用了遗传多样性小鼠品系：10种野生来源的小鼠品系（PGN 2、BFM/2、HMI、CAST/Ei、NJL、BLG 2、CHD、SWN、KJR、MSM），一种来源于所谓的花式小鼠（JF 1）的品系，以及一种标准实验室品系C57 BL/6。传统的测量方法揭示了各种关系：一些菌株没有显示出假设的高安培数，在中心区域停留时间较长，排便量较低之间的关联。我们的行为学方法显示，一些行为，如冻结和跳跃，没有观察到在C57 BL/6，但看到在一些野生衍生株。主成分分析，其中包括时间信息表明，这些菌株有不同的时间模式的适应新奇。
The open-field test is a commonly used apparatus in many behavioral studies. However, in most studies, temporal changes of details of behavior have been ignored. We thus examined open-field behavior as measured by both conventional indices and 12 ethograms supported by detailed temporal observation. To obtain a broader understanding, we used genetically diverse mouse strains: 10 wild-derived mouse strains (PGN2, BFM/2, HMI, CAST/Ei, NJL, BLG2, CHD, SWN, KJR, MSM), one strain derived from the so-called fancy mouse (JF1), and one standard laboratory strain, C57BL/6. Conventional measurements revealed a variety of relationships: some strains did not show the hypothesized association between high ambulation, longer stay in the central area, and low defecation. Our ethological approach revealed that some behaviors, such as freezing and jumping, were not observed in C57BL/6 but were seen in some wild-derived strains. Principal component analysis which included temporal information indicated that these strains had varied temporal patterns of habituation to novelty.