Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index.
Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index.
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发表时间：
2008-07
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通讯作者：
M. Wacker;M. Godard;Everlee H McCabe;J. Donnelly;J. Kelly
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作者：
M. Wacker;M. Godard;Everlee H McCabe;J. Donnelly;J. Kelly
背景血管紧张素转换酶（ACE）催化血管紧张素I到血管紧张素II的形成。在内含子16中发现了一种多态性，其中发现287个碱基对的alu序列在人群中存在（插入或I）或缺失（缺失或D）。ACE和肾素-血管紧张素系统的组分在脂肪组织中表达，因此ACE内的I/D多态性可能与肥胖相关。材料/方法本研究涉及两组不同的体重指数（BMI ≥ 30），主要由中年白人受试者（n=421）的基因分型。结果男性组间ACE基因I等位基因频率差异有统计学意义，BMI ≥ 30组I等位基因频率高于BMI ≤ 25组，但差异无统计学意义。结论：我们的研究结果表明，在关联的I/D多态性和BMI的性别差异。我们的研究结果不同于其他一些以前的研究，使用不同的人群表明，ACE I/D多态性可能与肥胖依赖于多种因素的差异。
BACKGROUND Angiotensin converting enzyme (ACE) catayzes the formation of angiotensin I to angiotensin II. A polymorphism has been identified in intron 16 in which a 287 base-pair alu sequence was found to be present (insertion or I) or absent (deletion or D) in the population. ACE and the components of the renin-angiotensin system are expressed in adipose tissue and therefore the I/D polymorphism within ACE may be associated with obesity. MATERIAL/METHODS This study involved genotyping two groups with differing body mass indexes (BMI or=30) that were composed primarily of middle-age Caucasian subjects (n=421). RESULTS The male groups differed significantly in allele frequency at the ACE locus with the I allele more frequent in the BMI >or=30 group (por=30 group also had a higher I allele frequency than the BMI <or=25 group, the difference is not significant. CONCLUSIONS Our results demonstrate a sex difference in the association of the I/D polymorphism and BMI. Our findings differ from some other previous studies using various population groups which indicate that the ACE I/D polymorphism may be differentially associated with obesity depending on multiple factors.