Type V Collagen in Health, Disease, and Fibrosis
Type V Collagen in Health, Disease, and Fibrosis
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DOI：
10.1002/ar.23330
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发表时间：
2016-05-01
影响因子：
2
通讯作者：
Lee, Danielle J.
中科院分区：
文献类型：
--
作者：
Mak, Ki M.;Png, Chien Yi M.;Lee, Danielle J.
V型胶原(COLV)是一种调节纤维形成的胶原蛋白。它至少有三种不同的分子异构体1(V)(2)2(V)、1(V)(3)和1(V)2(V)3(V)由三个不同的多肽链1(V)、2(V)和3(V)组合而成。V型胶原是细胞外基质(ECM)中相对较少的胶原蛋白。在形态上，COLV以异型纤维形式出现，含有I型胶原(Coli)、微丝或12纳米厚的纤维。COLV在多种间充质细胞中合成，其基因表达受转化生长因子和生长因子的调节。天然和变性的COLV虽然不能被间质胶原酶消化，但会被金属蛋白酶和明胶酶降解，从而促进ECM重塑。COLV与基质胶原蛋白和结构蛋白相互作用，赋予组织支架结构完整性。它结合基质大分子，调节细胞行为和功能。COLV与大肠杆菌在角膜和皮肤真皮中共同组装成异型纤维，是胶原纤维形成的主要调节因素。COLV缺乏与角膜透明度丧失和典型的Ehler-Danlos综合征有关，而COLV在癌症、肉芽组织、炎症、动脉粥样硬化和肺、皮肤、肾脏、脂肪组织和肝脏的纤维化中被发现过表达。含有3(V)链的COLV亚型参与调节胰岛细胞的功能。在肝脏中，COLV是ECM的一个微小但正常的组成部分。COLV的增加与早期和晚期的肝纤维化有关。COLV的新表位已被证明是一种有用的非侵入性血清生物标志物，用于评估实验性肝纤维化的纤维化进展和消退。COLV在健康、疾病和纤维化方面具有多功能。Anat Rec，299：613-629,2016。(C)2016威利期刊公司。
Type V collagen (COLV) is a regulatory fibril-forming collagen. It has at least three different molecular isoforms1(V)(2)2(V), 1(V)(3,) and 1(V)2(V)3(V)formed by combinations of three different polypeptide chains1(V), 2(V), and 3(V). COL V is a relatively minor collagen of the extracellular matrix (ECM). Morphologically, COLV occurs as heterotypic fibrils with type I collagen (COLI), microfilaments, or 12-nm-thick fibrils. COLV is synthesized in various mesenchymal cells and its gene expression is modulated by TGF- and growth factors. While resistant to digestion by interstitial collagenases, native and denatured COLV are degraded by metalloproteinases and gelatinases, thereby promoting ECM remodeling. COLV interacts with matrix collagens and structural proteins, conferring structural integrity to tissue scaffolds. It binds matrix macromolecules, modulating cellular behavior, and functions. COLV co-assembles with COLI into heterotypic fibrils in the cornea and skin dermis, acting as a dominant regulator of collagen fibrillogenesis. COLV deficiency is associated with loss of corneal transparency and classic Ehlers-Danlos syndrome, while COLV overexpression is found in cancer, granulation tissue, inflammation, atherosclerosis, and fibrosis of lungs, skin, kidneys, adipose tissue, and liver. COLV isoform containing the 3(V) chain is involved in mediating pancreatic islet cell functions. In the liver, COLV is a minor but regular component of the ECM. Increases in COLV are associated with both early and advanced hepatic fibrosis. The neoepitopes of COLV have been shown to be a useful noninvasive serum biomarker for assessing fibrotic progression and resolution in experimental hepatic fibrosis. COLV is multifunctional in health, disease, and fibrosis. Anat Rec, 299:613-629, 2016. (c) 2016 Wiley Periodicals, Inc.