Asthma Exacerbations: Pathogenesis, Prevention, and Treatment.

Asthma Exacerbations: Pathogenesis, Prevention, and Treatment.
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DOI:
10.1016/j.jaip.2017.05.001
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发表时间:
2017-07
期刊:
The journal of allergy and clinical immunology. In practice
影响因子:
--
通讯作者:
Busse WW
Busse WW
中科院分区:
其他
文献类型:
--
作者:
Castillo JR;Peters SP;Busse WW

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基于指南的哮喘管理侧重于疾病严重程度和选择适当的药物治疗来控制症状和降低恶化的风险。然而,无论哮喘的严重程度如何,通常尽管有最佳的药物治疗,患者仍可能出现症状的急性恶化和疾病控制的丧失。哮喘加重最常由病毒性呼吸道感染引起,特别是人鼻病毒。鉴于这些事件对哮喘发病率和卫生保健费用的重要性,我们将回顾哮喘恶化的常见煽动因素以及预防和治疗这些事件的方法。
Guideline-based management of asthma focuses on disease severity and choosing the appropriate medical therapy to control symptoms and reduce the risk of exacerbations. However, irrespective of asthma severity and often despite optimal medical therapy, patients may experience acute exacerbations of symptoms and a loss of disease control. Asthma exacerbations are most commonly triggered by viral respiratory infections, particularly with human rhinovirus. Given the importance of these events to asthma morbidity and health care costs, we will review common inciting factors for asthma exacerbations and approaches to prevent and treat these events.
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