The Roles of ANGPTL Families in Cancer Progression
The Roles of ANGPTL Families in Cancer Progression
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DOI：
10.7888/juoeh.41.317
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发表时间：
2019-09-01
期刊：
影响因子：
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通讯作者：
Endo, Motoyoshi
中科院分区：
文献类型：
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作者：
Endo, Motoyoshi
血管生成素在血管生成和造血干细胞的维持中发挥重要作用。血管生成素样蛋白（ANGPTL）被鉴定为结构上类似于血管生成素的蛋白质，并且ANGPTL家族现在由八个成员组成。ANGPTLs是一种分泌性蛋白质，有些ANGPTLs不仅是血管生成因子，而且还具有糖代谢、脂代谢等多种功能。氧化还原调节和慢性炎症。慢性炎症是癌症发生和癌症生长的关键因素之一。增殖、侵袭和转移。ANGPTL 2.3、4、6和7是促炎因子并调节癌症进展，而ANGPTL 1抑制肿瘤血管生成和转移。本文综述了ANGPTLs在肿瘤进展中的作用，并探讨了通过调控ANGPTLs表达来干扰肿瘤进展的可能性。
Angiopoietins play important roles in angiogenesis and the maintenance of hematopoietic stem cells. Angiopoietin-like proteins (ANGPTLs) are identified as proteins structurally similar to angiopoietins, and the ANGPTL family now consists of eight members. ANGPTLs are secretary proteins, and some ANGPTLs are not only angiogenic factors but also proteins with multiple functions such as glucose metabolism, lipid metabolism. redox regulation and chronic inflammation. Chronic inflammation is one of the key factors in carcinogenesis and cancer growth. proliferation, invasion and metastasis. ANGPTL 2.3, 4, 6 and 7 are pro-inflammatory factors and regulate cancer progression, while ANGPTL1 inhibits tumor angiogenesis and metastasis. In this review, we describe the roles of ANGPTLs in cancer progression and discuss the possibility of disturbing the progression of cancer by regulating ANGPTLs expression.