Rapid increase in the prevalence of metronidazole-resistant Helicobacter pylori in the Netherlands.
Rapid increase in the prevalence of metronidazole-resistant Helicobacter pylori in the Netherlands.
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DOI：
10.3201/eid0303.970320
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发表时间：
1997-07
影响因子：
11.8
通讯作者：
中科院分区：
文献类型：
--
作者：
1993年至1996年在一家荷兰医院和1993年和1996年在另外两家荷兰医院研究了幽门螺杆菌原发性甲硝唑耐药的患病率。所有胃窦活检标本培养均为H。pylori的患者进行了评价，但接受抗H. pylori治疗; 1，037 H. pylori菌株，均来自不同患者。1993年用纸片扩散法测定甲硝唑耐药性，1994 ~ 1996年用Epilipometer法测定甲硝唑耐药性。甲硝唑耐药率从1993年的7%（18/245）上升到1996年的32%（161/509）。1996年非溃疡性消化不良患者和非西欧患者比1993年多，但未观察到年龄和性别差异。在非溃疡性消化不良患者和消化性溃疡患者中观察到甲硝唑耐药性的相似增加，西欧人的甲硝唑耐药性患病率从1993年的5%增加到1996年的28%。
The prevalence of primary metronidazole resistance of Helicobacter pylori was studied in one Dutch hospital from 1993 to 1996 and in two additional Dutch hospitals in 1993 and 1996. All cultures of antral biopsy specimens yielding H. pylori in the study period were evaluated, except those from patients who had received anti-H. pylori treatment; 1,037 H. pylori strains, all from different patients were included. Metronidazole resistance was determined by disk diffusion in 1993 and by Epilipsometer-test in 1994 to 1996. Metronidazole resistance increased from 7% (18/245) in 1993 to 32% (161/509) in 1996. More patients with nonulcer dyspepsia and more non-Western European patients were seen in 1996 than in 1993, but age and sex differences were not observed. A comparable increase in metronidazole resistance was observed in both nonulcer dyspepsia patients and peptic ulcer patients, and the prevalence of metronidazole resistance in Western Europeans increased from 5% in 1993 to 28% in 1996.