A systems biology approach to multicellular and multi-generational radiation responses
A systems biology approach to multicellular and multi-generational radiation responses
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DOI：
10.1016/j.mrfmmm.2005.09.008
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发表时间：
2006-05-11
影响因子：
2.3
通讯作者：
Costes, Sylvain V.
中科院分区：
文献类型：
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作者：
Barcellos-Hoff, Mary Helen;Costes, Sylvain V.
最近的研究突出了辐照细胞和非辐照旁观者细胞之间的串扰，并发现了辐照细胞后代基因组不稳定的高频表型，这不能仅仅用辐射诱导的突变来解释。使用当前的辐射生物学范式很难解释这些多细胞和多代现象。辐射诱导的旁观者效应是多细胞对辐射的一种反应，表明多细胞生物体中的功能单位既不是基因组也不是细胞。在复杂的三维组织中，细胞功能由可溶性信号肽和细胞外基质提供的不溶性支架内的小分子协调。因此，适应性反应和辐射诱导的基因组不稳定性可能是辐射暴露后持续的信号扰动造成的。基于网络互连性和空间组织的系统生物学原理的辐射响应模型应该调和这些细胞表型在组织和生物体的高级结构内的明显矛盾。(c)2005 Elsevier B.V.保留所有权利。
Recent studies have highlighted crosstalk between irradiated cells and non-irradiated bystander cells and have uncovered high-frequency phenotypes of genomic instability in the progeny of irradiated cells that cannot be solely explained by radiation-induced mutation. It is difficult to explain these multicellular and multi-generational phenomena using the current paradigm of radiation biology. Radiation-induced bystander effect is a type of multicellular response to radiation that illustrates that the unit of function in multicellular organisms is neither the genome nor the cell. Cell function in complex three-dimensional tissues is coordinated by soluble signaling peptides and by small molecules within the context of insoluble scaffolding provided by the extracellular matrix. Adaptive response and radiation-induced genomic instability could thus result from persistent signaling perturbations following radiation exposures. A model of radiation response based on the systems biology principles of network interconnectivity and spatial organization should reconcile the apparent contradiction of these cellular phenotypes within the higher order structure of tissues and organisms. (c) 2005 Elsevier B.V. All rights reserved.