Gender Differences in the Association between Melatonin Secretion and Diabetes in Elderly: the HEIJO-KYO Cohort.
Gender Differences in the Association between Melatonin Secretion and Diabetes in Elderly: the HEIJO-KYO Cohort.
复制标题
老年人褪黑激素分泌与糖尿病之间关系的性别差异：HEIJO-KYO 队列。
DOI：
10.1111/cen.13842
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发表时间：
2018
期刊：
影响因子：
3.2
通讯作者：
Saeki K.
中科院分区：
文献类型：
--
作者：
Obayashi K;Yamagami Y;Iwamoto J;Kurumatani N;Saeki K.
目的研究褪黑素对胰岛的保护作用，降低胰岛素抵抗；因此，它可能有助于预防糖尿病。流行病学资料显示，女性护士中褪黑激素分泌减少与糖尿病发病率增高有关。这种关联在一般人群中是未知的。我们评估了包括男女在内的普通人群中褪黑激素分泌与糖尿病之间的关系。DesignCross截面研究。参与者共纳入1096名社区老年男性（n = 519）和女性（n = 577）（平均年龄71.8岁）。测量夜间尿6 -亚砜褪黑素排泄（UME）和糖尿病患病率。结果中位UME为6.7 μg（四分位数范围为4.0 ~ 10.5）；糖尿病患病率男性为17.5%，女性为10.7%。糖尿病患病率在男性中随着UME四分位数的增加而下降（p趋势= 0.009），但在女性中没有（p趋势= 0.96）。在一项多变量logistic回归分析中，校正了潜在的混杂因素，如年龄、吸烟和饮酒习惯、经济状况、热量摄入和体育活动，在男性中，UME最高四分位数组与最低四分位数组相比，糖尿病的优势比（OR）显著降低（OR, 0.35; 95% CI, 0.17‐0.70；P= 0.003），但女性中没有（OR, 0.94; 95% CI, 0.45‐1.95；P= 0.87）。在调整临床参数或使用连续UME数据后，在分析中观察到一致的结果。结论男性血清素分泌与糖尿病呈显著负相关，而女性无显著负相关。这种关联独立于几个重要的混杂因素。
ObjectiveReportedly, melatonin protects the pancreatic islets and decreases insulin resistance; thus, it may contribute to preventing diabetes. Epidemiological data suggested that lower melatonin secretion is associated with higher incidence of diabetes in female nurses. Such associations are unknown in the general population. We evaluated the association between melatonin secretion and diabetes in a general population, including both genders.DesignCross‐sectional study.ParticipantsA total of 1096 community‐based elderly males (n = 519) and females (n = 577) (mean age, 71.8 years) were enrolled.MeasurementsOvernight urinary 6‐sulfatoxymelatonin excretion (UME) and diabetes prevalence were measured.ResultsThe median UME was 6.7 μg (interquartile range, 4.0‐10.5); the prevalence of diabetes was 17.5% in males and 10.7% in females. The prevalence of diabetes decreased with increasing UME quartiles among males (Pfor trend = 0.009) but not among females (Pfor trend = 0.96). In a multivariable logistic regression analysis adjusting for potential confounding factors, such as age, smoking and drinking habits, economic status, caloric intake, and physical activity, the odds ratio (OR) for diabetes was significantly lower in the highest UME quartile group compared with the lowest quartile group among males (OR, 0.35; 95% CI, 0.17‐0.70;P= 0.003) but not females (OR, 0.94; 95% CI, 0.45‐1.95;P= 0.87). Consistent results were observed in the analysis after adjusting for clinical parameters or using continuous UME data.ConclusionsMelatonin secretion was significantly and inversely associated with diabetes in males but not in females. This association was independent of several important confounding factors.