EVIDENCE IN SUPPORT OF A SELF-PERPETUATING HLA-DR-DEPENDENT DELAYED-TYPE CELL REACTION IN RHEUMATOID-ARTHRITIS
EVIDENCE IN SUPPORT OF A SELF-PERPETUATING HLA-DR-DEPENDENT DELAYED-TYPE CELL REACTION IN RHEUMATOID-ARTHRITIS
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DOI：
10.1073/pnas.79.11.3632
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
WIGZELL, H
中科院分区：
文献类型：
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作者：
KLARESKOG, L;FORSUM, U;WIGZELL, H
通过观察类风湿滑膜组织和皮肤病变在迟发性超敏反应中的相似性，以及大量表达HLA-DR的巨噬细胞/树突状细胞附近的辅助性T淋巴细胞的相似之处，形成了一个概念，即局部巨噬细胞依赖的辅助性T细胞激活在类风湿关节中的重要性类似于迟发性皮肤反应。对悬浮滑膜细胞的体外研究被用来测试和验证这些想法。正常滑膜内膜中表达HL A-DR的细胞可以像表皮朗格汉斯细胞一样，介导T细胞的活化。类风湿滑膜组织中大量表达人类白细胞抗原-DR的巨噬细胞/树突状细胞是异质性的，可以有效地激活或抑制T淋巴细胞的增殖。类风湿T细胞的特异性可以在自体滑膜抗原提呈细胞的帮助下进行分析；在3名患者中报告了特异性抗胶原II型反应。
Originating from observations on similarities between the rheumatoid synovial tissue and skin lesions in delayed-type hypersensitivity reactions, similarities as to massive infiltrates of helper T lymphocytes close to HLA-DR-expressing macrophage/dendritic cells, a notion is formed on the importance of local macrophage-dependent helper T-cell activation in the rheumatoid joint similar to that in a delayed-type skin reaction. In vitro studies on suspended synovial cells were used to test and qualify these ideas. HLA-DR-expressing cells in normal synovial intima can, like epidermal Langerhans cells, mediate T-cell activation. The large numbers of rheumatoid synovial HLA-DR-expressing macrophage-like/dendritic cells are heterogeneous and mediate either efficient activation or suppression of T-lymphocyte proliferation. Specificity of rheumatoid T cells can be analyzed with the help of autologous synovial antigen-presenting cells; a specific anti-collagen type II response is reported in 3 patients.