Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors
Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors
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DOI：
10.1128/jvi.02328-14
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发表时间：
2015-01-01
影响因子：
5.4
通讯作者：
DeCaprio, James A.
中科院分区：
文献类型：
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作者：
Berrios, Christian;Jung, Joonil;DeCaprio, James A.
马拉维多瘤病毒（MWPyV）是最近发现的一种人类多瘤病毒。MWPyV VP1的血清学表明，感染经常发生在儿童时期，在成人中的流行率达到75%。MWPyV小T抗原（ST）结合蛋白磷酸酶2A（PP2A），大T抗原（LT）结合pRb、p107、p130和p53。然而，MWPyV LT的稳定性低于猿猴病毒40（SV40）LT，并且不能促进正常细胞的生长。该报告证实，MWPyV是一种广泛存在的表达T抗原的人类病毒，具有低转化潜力。
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.