Successful treatment of XDR-TB patient in Tanzania: report of the first XDR-TB patient
Successful treatment of XDR-TB patient in Tanzania: report of the first XDR-TB patient
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DOI：
10.1177/0049475519833554
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发表时间：
2019-07-01
期刊：
影响因子：
0.6
通讯作者：
Mpondo, Bonaventura C. T.
中科院分区：
文献类型：
--
作者：
Lyakurwa, Dennis;Lyimo, Johnson;Mpondo, Bonaventura C. T.
耐药结核病正在成为一个新的严重的公共卫生挑战。我们提出了坦桑尼亚第一例确诊的广泛耐药结核病，患者既往曾接触抗结核药物，并有南非监禁史。治疗方案中加入贝达喹啉导致痰菌转阴。经过总共30个月的治疗，他被宣布治愈，在整个随访期间保持临床稳定和培养阴性。密切监测对管理耐药结核病例很重要，需要进行良好的监测，以发现耐药结核，防止进一步传播。
Drug-resistant tuberculosis (TB) is emerging as a new and serious public health challenge. We present the first case with confirmed extensive drug-resistant TB in Tanzania in a patient who had prior exposure to anti-TB drugs and a history of imprisonment in South Africa. The addition of bedaquiline to the treatment regime resulted in positive to negative sputum conversion. After a total of 30 months on treatment he was declared cured, remaining clinically stable and culture-negative throughout the follow-up. Close monitoring is important in managing drug-resistant TB cases, and good surveillance is required to detect drug-resistant TB to prevent further transmission.