Insight into a neuron's preferential susceptibility to oxidative stress
Insight into a neuron's preferential susceptibility to oxidative stress
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DOI：
10.1042/bst20130245
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发表时间：
2013-12-01
影响因子：
3.9
通讯作者：
Bell, Karen F. S.
中科院分区：
文献类型：
--
作者：
Bell, Karen F. S.
神经元比星形胶质细胞更容易受到氧化应激的影响，其原因尚未完全阐明。理解有助于这种增强的脆弱性的细胞和分子机制是旨在改善神经元健康和对氧化应激的恢复力的努力的关键，特别是在神经退行性疾病的背景下，其特征在于进行性功能障碍和神经元丢失，并且其中氧化应激被认为是一个中心病因学贡献者。生物因素可能会影响神经元对氧化应激的敏感性，在正常和神经退行性疾病的背景下，在本文章中进行了审查，重点是固有的神经元细胞类型的属性和属性相关的神经元依赖周围的星形胶质细胞。
Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health and resilience to oxidative stress, particularly in the context of neurodegenerative disease, which is characterized by progressive dysfunction and loss of neurons specifically, and in which oxidative stress is considered a central aetiological contributor. Biological factors which may influence neuronal susceptibility to oxidative stress, in normal and neurodegenerative contexts, are reviewed in the present article, with a focus on properties intrinsic to the neuronal cell type and on properties related to neuronal reliance on surrounding astrocytes.