Serum leptin levels in post-hepatitis liver cirrhosis
Serum leptin levels in post-hepatitis liver cirrhosis
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DOI：
10.1016/s0168-8278(00)80157-9
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发表时间：
2000-07-01
影响因子：
25.7
通讯作者：
Gasbarrini, G
中科院分区：
文献类型：
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作者：
Greco, AV;Mingrone, G;Gasbarrini, G
背景/目的：关于瘦素在与营养不良相关的临床状况（如肝硬化）中的作用的信息很少。因此，研究了不同Child- pugh评分、肝炎后肝硬化和胰岛素敏感性患者的血清瘦素行为，并将其与酗酒的Child C患者进行了比较。方法：将64例51 ~ 62岁不同程度肝炎后肝硬化或Child C型酒精性肝硬化患者与15例年龄匹配的对照组进行比较。通过皮褶厚度估计身体成分。测定血清瘦素、葡萄糖、胰岛素。结果：在肝炎后患者中，随着Child- pugh评分的恶化，瘦素水平显著降低(男性：Child C组为2.94+/-1.61，对照组为6.78+/-2.49 ng/ml, p
Background/Aims: Little information is available on the involvement of leptin in clinical conditions associated with malnutrition, such as liver cirrhosis. The behaviour of serum leptin in patients with different Child-Pugh score, post-hepatitis liver cirrhosis and insulin sensitivity has therefore been investigated and compared with that in alcoholic Child C patients.Methods: Sixty-four patients, aged 51 to 62 years, with different degrees of post-hepatitis cirrhosis or Child C alcoholic cirrhosis were compared with 15 age-matched control subjects. Body composition was estimated by skinfold thickness. Serum leptin, glucose and insulin were assayed.Results: In post-hepatitis patients a significant reduction in leptin levels was observed as the Child-Pugh score worsened (men: 2.94+/-1.61 in Child C vs 6.78+/-2.49 ng/ml in controls, p