Neurodegenerative Disease Mortality among Former Professional Soccer Players
Neurodegenerative Disease Mortality among Former Professional Soccer Players
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DOI：
10.1056/nejmoa1908483
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发表时间：
2019-11-07
影响因子：
158.5
通讯作者：
Stewart, William
中科院分区：
文献类型：
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作者：
Mackay, Daniel F.;Russell, Emma R.;Stewart, William
背景：神经退行性疾病在参加接触性运动的优秀运动员中有报道。前职业足球运动员神经退行性疾病的发病率尚未得到很好的表征。方法我们进行了一项回顾性队列研究，比较了7676名前职业足球运动员（从苏格兰球员数据库中识别）与23，028名根据性别与球员相匹配的普通人群对照者的神经退行性疾病死亡率。、年龄和社会剥夺程度。根据死亡证明确定死亡原因。还比较了两个队列中用于治疗痴呆症的药物数据。处方信息来自国家处方信息系统。结果在18年的中位数，1180名前足球运动员（15.4%）和3807名对照（16.5%）死亡。在70岁之前，前运动员的全因死亡率低于对照组，70岁之后则高于对照组。前运动员缺血性心脏病的死亡率低于对照组（风险比，0.80; 95%可信区间[CI]，0.66 - 0.97; P=0.02），肺癌的死亡率也是如此（风险比，0.53; 95%可信区间[CI]，0.40 - 0.70; P = 0.02）。
Background Neurodegenerative disorders have been reported in elite athletes who participated in contact sports. The incidence of neurodegenerative disease among former professional soccer players has not been well characterized. Methods We conducted a retrospective cohort study to compare mortality from neurodegenerative disease among 7676 former professional soccer players (identified from databases of Scottish players) with that among 23,028 controls from the general population who were matched to the players on the basis of sex, age, and degree of social deprivation. Causes of death were determined from death certificates. Data on medications dispensed for the treatment of dementia in the two cohorts were also compared. Prescription information was obtained from the national Prescribing Information System. Results Over a median of 18 years, 1180 former soccer players (15.4%) and 3807 controls (16.5%) died. All-cause mortality was lower among former players than among controls up to the age of 70 years and was higher thereafter. Mortality from ischemic heart disease was lower among former players than among controls (hazard ratio, 0.80; 95% confidence interval [CI], 0.66 to 0.97; P=0.02), as was mortality from lung cancer (hazard ratio, 0.53; 95% CI, 0.40 to 0.70; P