Overweight and obesity in pediatric liver transplant recipients: prevalence and predictors before and after transplant, United Network for Organ Sharing Data, 1987-2010.
Overweight and obesity in pediatric liver transplant recipients: prevalence and predictors before and after transplant, United Network for Organ Sharing Data, 1987-2010.
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DOI：
10.1111/j.1399-3046.2011.01598.x
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发表时间：
2012-02
影响因子：
1.3
通讯作者：
Rosenthal P
中科院分区：
文献类型：
--
作者：
Perito ER;Glidden D;Roberts JP;Rosenthal P
肥胖在成年肝移植受者和健康的美国儿童中非常常见。关于小儿肝移植受者移植后肥胖的患病率或危险因素知之甚少。分析了1987-2010年美国所有6个月-20岁儿童肝移植的UNOS数据。根据CDC指南，受试者被分类为体重不足、正常体重、超重或肥胖。移植时和移植后体重状况的预测因素采用多变量logistic回归进行确定。在3043名6-24个月大的儿童中，14%的人超重。在4658例移植时年龄在2-20岁的受试者中，16%超重，13%肥胖。在调整年龄、种族、初步诊断、移植年份和移植类型后，在所有年龄组中，移植时超重/肥胖的儿童在移植后1年、2年和5年更有可能超重/肥胖。移植时的体重状况与移植后10年的超重/肥胖无关。在长期随访中，移植后肥胖的患病率仍然很高，从20%到50%，这取决于移植时的年龄和体重状况。移植时的体重状况是移植后超重/肥胖的最强预测因素。为了优化儿科肝移植受者的长期结局，监测肥胖及其合并症非常重要。
Obesity is extremely common in adult liver transplant recipients and healthy U.S. children. Little is known about the prevalence or risk factors for post-transplant obesity in pediatric liver transplant recipients. UNOS data on all U.S. liver transplants 1987–2010 in children 6 months–20 yr at transplant were analyzed. Subjects were categorized as underweight, normal weight, overweight, or obese by CDC guidelines. Predictors of weight status at and after transplant were identified using multivariate logistic regression. Of 3043 children 6–24 months at transplant, 14% were overweight. Of 4658 subjects 2–20 yr at transplant, 16% were overweight and 13% obese. Children overweight/obese at transplant were more likely to be overweight/obese at one, two, and five yr after transplant in all age groups after adjusting for age, ethnicity, primary diagnosis, year of transplant, and transplant type. Weight status at transplant was not associated with overweight/ obesity by 10 yr after transplant. The prevalence of post-transplant obesity remained high in long-term follow-up, from 20% to 50% depending on age and weight status at transplant. Weight status at transplant is the strongest predictor of post-transplant overweight/obesity. To optimize long-term outcomes in pediatric liver transplant recipients, monitoring for obesity and its comorbidities is important.