Poly(Amino Acid) Coordination Nanoparticle as a Potent Sonosensitizer for Cancer Therapy
Poly(Amino Acid) Coordination Nanoparticle as a Potent Sonosensitizer for Cancer Therapy
复制标题
多(氨基酸)配位纳米粒子作为一种有效的肿瘤治疗声敏剂
DOI：
10.1021/acsabm.0c01383
复制
发表时间：
2021-01-18
影响因子：
4.7
通讯作者：
Shen, Heyun
中科院分区：
文献类型：
--
作者：
Bai, Lintao;Wang, Mingkun;Shen, Heyun
声动力学疗法（SDT）因其较光疗更深的组织穿透深度而受到广泛关注。然而，开发在肿瘤缺氧环境中具有高声敏功效的声敏剂仍然是一个重大挑战。在此，我们制作了一个聚（氨基酸）配位纳米粒子（PFHF）作为一个有效的声敏剂具有很大的生物相容性和高的羟基自由基（（OH）-O-中心点）-生成能力，有效的SDT。通过X射线吸收精细结构和密度泛函理论分析，确定PFHF为六配位结构。超声波可激发PFHF，使H2O直接裂解为（OH）-O中心点，实现非氧依赖性SDT。此外，负载阿霉素的PFHF实现了显著的协同化学声动力学治疗效果，肿瘤抑制率为89%。聚氨基酸配位纳米粒子具有良好的生物相容性和非氧依赖性，为声敏剂的合理设计提供了思路。
Sonodynamic therapy (SDT) has gained wide-spread attention owning to its much deeper tissue penetration depth compared with phototherapy. However, developing sonosensitizers with high sonosensitization efficacy in a tumor hypoxic environment is still a significant challenge. Herein, we fabricated a poly(amino acid) coordination nanoparticle (PFHF) as a potent sonosensitizer with great biocompatibility and high hydroxyl radical ((OH)-O-center dot)-generation capacity for efficient SDT. PFHF was identified as a hexa-coordination structure by X-ray absorption fine structure and density functional theory. Furthermore, PFHF could be excited by ultrasound, which directly cleaved H2O into (OH)-O-center dot, achieving oxygen-independent SDT. In addition, doxorubicin-loaded PFHF achieved a significant synergistic chemo-sonodynamic therapeutic effect with a tumor inhibition rate of 89%. The poly(amino acid) coordination nanoparticle with good biocompatibility and oxygen-independent ability could provide an idea for the rational design of sonosensitizers.