INTERRELATIONSHIPS OF CIRCULATING MATERNAL STEROID CONCENTRATIONS IN 3RD TRIMESTER PREGNANCIES .2. C-18 AND C-19 STEROIDS - ESTRADIOL, ESTRIOL, DEHYDROEPIANDROSTERONE, DEHYDROEPIANDROSTERONE SULFATE, DELTA-5-ANDROSTENEDIOL, DELTA-4-ANDROSTENEDIONE, TESTOSTERONE, AND DIHYDROTESTOSTERONEE
INTERRELATIONSHIPS OF CIRCULATING MATERNAL STEROID CONCENTRATIONS IN 3RD TRIMESTER PREGNANCIES .2. C-18 AND C-19 STEROIDS - ESTRADIOL, ESTRIOL, DEHYDROEPIANDROSTERONE, DEHYDROEPIANDROSTERONE SULFATE, DELTA-5-ANDROSTENEDIOL, DELTA-4-ANDROSTENEDIONE, TESTOSTERONE, AND DIHYDROTESTOSTERONEE
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DOI：
10.1210/jcem-48-1-139
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发表时间：
1979-01-01
影响因子：
5.8
通讯作者：
MARSHALL, JR
中科院分区：
文献类型：
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作者：
BUSTER, JE;CHANG, RJ;MARSHALL, JR
本报告描述了孕龄提前对母体循环浓度 17.β.-雌二醇 (E2)、雌三醇 (E3)、脱氢表雄酮 (D)、脱氢表雄酮硫酸盐 (D-S)、.DELTA.5-雄烯二醇 (.DELTA.5diol)、.DELTA.4-雄烯二酮的总时间趋势影响 (.DELTA.4A)、睾酮 (T) 和二氢睾酮 (DHT) 在从 19 名孕龄为 26-40 周的正常孕妇获得的 155 个连续血液样本中进行。只有 E2、E3 和 D-S 显示聚合时间趋势效应。 Log (E2) 绘制为 26-40 周的线性正倾斜曲线。 Log (E3) 绘制为正倾斜曲线，明显比 log (E2) 陡峭 (P < 0.05)。 Log (D-S) 绘制成负斜率曲线，它反映了 log (E2) 的模式，但不能与 log (E2) 统计相关，除非它们的斜率符号相反，这两者都与零斜率显着不同 (P < 0.05)。 .DELTA.4A、T、DHT、.DELTA.5diol 和 D 没有表现出总时间趋势；然而，在26-28周和38-40周之间，DELTA.4A、T、DHT和DELTA.5二醇的宽范围、同动波动通过对数平均图的比较及时得到证实，并且通过对另一个C19类固醇进行回归来及时证实其幅度。 D 与其他 C19 类固醇几乎没有关联。除 T 外，所有 C19 类固醇均以非妊娠浓度循环，这意味着胎盘很少将这些类固醇分泌到母体循环中。
This report describes aggregate time trend effects of advancing gestational age on circulating maternal concentrations of 17.beta.-estradiol (E2), estriol (E3), dehydroepiandrosterone (D), dehydroepiandrosterone sulfate (D-S), .DELTA.5-androstenediol (.DELTA.5diol), .DELTA.4-androstenedione (.DELTA.4A), testosterone (T), and dihydrotestosterone (DHT) in a sequential series of 155 blood samples obtained from 19 normal pregnant women ranging from 26-40 wk gestational age. Only E2, E3, and D-S show aggregate time trend effects. Log (E2) plots as a linear positive sloping curve from 26-40 wk. Log (E3) plots as a positive sloping curve that is significantly steeper than log (E2) (P < 0.05). Log (D-S) plots into a negative sloping curve which mirrors the pattern for log (E2) but cannot be statistically associated with log (E2) except for the opposite sign of their slopes, which are both significantly different from a zero slope (P < 0.05). .DELTA.4A, T, DHT, .DELTA.5diol, and D show no aggregate time trends; however wide, comoving undulations for .DELTA.4A, T, DHT, and .DELTA.5diol between 26-28 and 38-40 wk are confirmed in time by comparison of log mean plots and in magnitude by regressing the C19 steroids on 1 another. D shows virtually no association with the other C19 steroids. All C19 steroids, except for T, circulate at nonpregnant concentrations, implying that there is little placental secretion of these steroids into the maternal circulation.