The molecular biology of selenocysteine.
The molecular biology of selenocysteine.
复制标题
DOI：
10.1515/bmc-2013-0007
复制
发表时间：
2013-08
影响因子：
--
通讯作者：
Copeland PR
中科院分区：
文献类型：
--
作者：
Gonzalez-Flores JN;Shetty SP;Dubey A;Copeland PR
硒是人体必需的微量元素，以硒半胱氨酸(Sec)的形式存在于人体的25种蛋白质中。这种氨基酸的加入在分子生物学中被证明是一个有趣的问题，因为SEC是由终止密码子UGA编码的。在规范的翻译延长机制的顶层是一组仅存在于结合这一重要氨基酸的因素。这一过程发生的机制，放在硒蛋白生物学的背景下，是本综述的重点。
Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a set of factors that exist solely to incorporate this important amino acid. The mechanism by which this process occurs, put into the context of selenoprotein biology, is the focus of this review.