Plasma androgen concentrations in several species of Old and New World monkeys.
Plasma androgen concentrations in several species of Old and New World monkeys.
复制标题
几种新旧大陆猴类的血浆雄激素浓度。
作者：
C. A. Snipes;M. Forest;C. Migeon
成年雄性（14 kg）恒河猴外周血血浆中未结合睾酮的浓度比成年男性血浆中的浓度高约50%。性不成熟的猴子（青春期早期，5公斤）的睾酮浓度约为成年水平的1/10。在未成熟的恒河猴中，睾酮与雄烯二酮的比例小于1，而在成年动物中为3或更高。在成熟动物中，通过1：5稀释的血浆平衡透析测定的睾酮与蛋白质的结合百分比为96.2%;在未成熟恒河猴中显著（p<0.01）更高（98.0%）。另一方面，成熟对雄烯二酮和脱氢表雄酮的结合率没有影响。尽管两个年龄组之间的睾酮结合略有差异，但恒河猴性成熟期间雄激素浓度的大幅变化似乎不是由于与血浆蛋白结合的百分比变化所致。雄激素浓度。
The concentration of unconjugated testosterone in peripheral blood plasma of adult male (14 kg) rhesus macaques was about 50% greater than that in plasma of adult male humans. The testosterone concentration in sexually immature monkeys (early adolescence, 5 kg) is of the order of 1/10 the adult level. In immature rhesus the ratio of testosterone to androstenedione was less than 1, whereas it was 3 or more in adult animals. The percentage binding of testosterone to proteins as measured by equilibrium dialysis with plasma diluted 1:5 was 96.2 % in mature animals; it was significantly (p<0.01) greater in immature rhesus (98.0%). On the other hand, maturation had no effect on the percentage binding of androstenedione anddehydroepiandrosterone. Despite the slight difference in testosterone binding between the 2 age groups, it would not appear that the large changes in androgen concentrations during sexual maturation of rhesus are due to changes in percentage binding to plasma proteins. Androgen concentrations ...