Nitrogen–Sulfur-Doped Graphene Quantum Dots with Metal Ion-Resistance for Bioimaging
Nitrogen–Sulfur-Doped Graphene Quantum Dots with Metal Ion-Resistance for Bioimaging
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DOI：
10.1021/acsanm.9b01309
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发表时间：
2019-10
影响因子：
5.9
通讯作者：
Zackery S Schroer;Yingfen Wu;Yuqian Xing;Xu Wu;Xiao Liu;Xu Wang;Onnica G Pino;Chuanmin Zhou-
中科院分区：
文献类型：
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作者：
Zackery S Schroer;Yingfen Wu;Yuqian Xing;Xu Wu;Xiao Liu;Xu Wang;Onnica G Pino;Chuanmin Zhou-
由于杂原子掺杂石墨烯量子点的杂原子官能团与生物系统中常见金属离子结合导致荧光猝灭，因此开发用于生物成像的超稳定高荧光石墨烯量子点（GQDs）仍然是一个挑战。在这里，我们开发了一种简单的水热法制备氮硫掺杂GQDs （NS-GQDs）。NS-GQDs的荧光信号在不同金属离子的存在下具有很高的稳定性。利用天门冬氨酸和半胱氨酸两种天然产物作为碳前体和杂原子（氮和硫）源。所制得的NS-GQDs在400 nm激发下的量子产率高达19.31.7%，最大发射波长为480 nm。x射线光电子能谱（XPS）、能谱（EDS）和傅里叶变换红外光谱（FTIR）等元素分析表明，NS-GQDs表面存在-NH2和-SH基团。除了……
The development of ultra-stable and highly fluorescent heteroatoms-doped graphene quantum dots (GQDs) for bioimaging remains a challenge due to the fluorescence quenching caused by binding between the heteroatoms-based functional groups of the GQDs and common metal ions in biological systems. Here, we developed a facile hydrothermal method to prepare nitrogen-sulfur doped GQDs (NS-GQDs). The fluorescence signals of the NS-GQDs are highly stable in the existence of different metal ions. Two natural products, aspartic acid and cysteine, were utilized as the carbon precursors and heteroatomic (nitrogen and sulfur) sources. The produced NS-GQDs showed a quantum yield up to 19.3 1.7 % with a maximum emission of 480 nm under the excitation of 400 nm. The elemental analysis, including X-ray photoelectron spectroscopy (XPS) and energy dispersive spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR), clearly demonstrated the presence of –NH2 and –SH groups on the surface of the NS-GQDs. Addition...