Sympathetic neuroaxonal dystrophy in the aged rat pineal gland.
Sympathetic neuroaxonal dystrophy in the aged rat pineal gland.
复制标题
老年大鼠松果体交感神经轴突营养不良。
DOI：
10.1016/j.neurobiolaging.2005.08.005
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Beaudet,LucieN
中科院分区：
文献类型：
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作者：
Schmidt,RobertE;Dorsey,DeniseA;Parvin,CurtisA;Beaudet,LucieN
老年人和大鼠松果体昼夜褪黑激素分泌功能障碍被认为是其交感神经支配功能丧失的反映。我们的超微结构神经病理学研究老年（24个月大）Fischer-344和Sprague-Dawley大鼠的松果体交感神经支配的神经末梢的损失，以及神经轴索营养不良（NAD）的发展，一个超微结构独特的远端轴突病变，远远超过了年轻的控制大鼠。酪氨酸羟化酶的免疫定位证实了年龄相关的正常去甲肾上腺素能神经支配和NAD的发展损失。与雄性大鼠相比，老年雌性大鼠中NAD的发生率更高，与Fischer-344大鼠相比，老年雌性Sprague-Dawley大鼠中NAD的发生率尤其严重。与年轻对照组相比，雌性和雄性老年Fischer-344大鼠的松果体NGF含量分别显著增加或不变。大鼠松果体是一个敏感的实验模型，定量超微结构检查年龄相关的神经病理学变化的神经末梢节后去甲肾上腺素能交感神经轴突，变化可能反映了类似的变化，在弥漫性分布的交感神经支配的其他目标终末器官。
Dysfunction of circadian melatonin production by the pineal gland in aged humans and rats is thought to reflect the functional loss of its sympathetic innervation. Our ultrastructural neuropathologic studies of the sympathetic innervation of the pineal gland of aged (24 months old) Fischer-344 and Sprague–Dawley rats showed loss of nerve terminals as well as the development of neuroaxonal dystrophy (NAD), an ultrastructurally distinctive distal axonopathy, far in excess of that in young control rats. Immunolocalization of tyrosine hydroxylase confirmed the age-related loss of normal noradrenergic innervation and development of NAD. NAD was more frequent in aged female rats compared to males and was particularly severe in aged female Sprague–Dawley rats compared to Fischer-344 rats. Pineal NGF content was significantly increased or unchanged in female and male aged Fischer-344 rats, respectively, compared to young controls. The rat pineal is a sensitive experimental model for the quantitative ultrastructural examination of age-related neuropathological changes in nerve terminals of postganglionic noradrenergic sympathetic axons, changes which may reflect similar changes in the diffusely distributed sympathetic innervation of other targeted endorgans.