IDENTIFICATION OF MUTAGENIC COMPOUNDS FORMED DURING CHLORINATION OF HUMIC-ACID
IDENTIFICATION OF MUTAGENIC COMPOUNDS FORMED DURING CHLORINATION OF HUMIC-ACID
复制标题
DOI：
10.1016/0165-1218(85)90105-3
复制
发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
SCHENCK, KM
中科院分区：
文献类型：
--
作者：
MEIER, JR;RINGHAND, HP;SCHENCK, KM
正在研究腐殖酸氯化产物，以确定水氯化过程中形成致突变性的化学物质。在本报告中，19个氯代有机化合物已被确定和量化的醚提取物的氯化腐殖酸溶液。其中10种化合物，包括一些氯化丙酮和氯化丙烯醛，在沙门氏菌/微粒体致突变试验中是直接作用的致突变剂。已发现氯取代基的位置是这两类化合物致突变活性的重要因素。当单独或作为复合物进行试验时，迄今为止鉴定的化合物的总致突变性仅占总TA 100致突变性的7-8%，不到腐植酸氯化过程中形成的TA 98致突变性的2%。在腐殖酸氯化反应中加入溴化物会导致形成的致突变性水平增加2倍。
Humic acid chlorination products are being studied in an effort to identify the chemicals responsible for the mutagenicity formed during water chlorination. In the present report, 19 chlorinated organic compounds have been identified and quantified in ether extracts of chlorinated humic acid solutions. Ten of these compounds, including a number of chlorinated propanones and chlorinated propenals, are directacting mutagens in the Salmonella/microsome mutagenicity assay. The position of the chlorine substituent has been found to be an important factor in the mutagenic activity of these two classes of compounds. The total mutagenicity of the compounds identified thus far, when tested either individually or as a composite, accounts for only 7-8% of the total TA100 mutagenicity, and less than 2% of the TA98 mutagenicity formed during humic acid chlorination. The addition of bromide to the humic acid chlorination reaction results in up to a 2-fold increase in the level of mutagenicity formed.