IMPACT OF CIGARETTE SMOKING ON MORTALITY IN HIV-POSITIVE AND HIV-NEGATIVE VETERANS
IMPACT OF CIGARETTE SMOKING ON MORTALITY IN HIV-POSITIVE AND HIV-NEGATIVE VETERANS
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DOI：
10.1521/aeap.2009.21.3_supp.40
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发表时间：
2009-06-01
影响因子：
1.8
通讯作者：
Justice, Amy C.
中科院分区：
文献类型：
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作者：
Crothers, Kristina;Goulet, Joseph L.;Justice, Amy C.
目前尚不清楚吸烟是否会给hiv阳性患者带来与hiv阴性患者相似的死亡风险。我们比较了1034名HIV阳性的退伍军人和739名HIV阴性的退伍军人的总体死亡率，这些退伍军人参加了2001-2002年的退伍军人老龄化队列5现场研究。校正死亡率发生率比（IRR）采用泊松回归计算。在未调整和调整分析中，艾滋病毒阳性退伍军人的死亡率根据吸烟状况和包龄均显著增加（艾滋病毒阳性当前吸烟者的调整IRR为2.31,95%可信区间[CI] 1.53-3.49，艾滋病毒阴性当前吸烟者的调整IRR为1.32,95%可信区间[CI] 0.67-2.61）。根据吸烟状况和包龄，共病发生率也显著增加。目前吸烟与不良预后有关；即使是较低水平的暴露对感染艾滋病毒的退伍军人也是有害的。这些发现支持有必要改进戒烟工作，并研究感染艾滋病毒的吸烟者死亡率增加的机制和疾病。
It is unknown whether smoking confers similar mortality risk in HIV-positive as in HIV-negative patients. We compared overall mortality stratified by HIV and smoking of 1,034 HIV-positive block-matched to 739 HIV-negative veterans, enrolled 2001-2002 in the Veterans Aging Cohort 5 Site Study. Adjusted incidence rate ratios (IRR) for mortality were calculated using Poisson regression. Mortality was significantly increased in HIV-positive veterans according to both smoking status and pack-years in unadjusted and adjusted analyses (adjusted IRR 2.31, 95% confidence interval [CI] 1.53-3.49 for HIV-positive current smokers and IRR 1.32, 95% CI 0.67-2.61 for HIV-negative current smokers). Comorbid diseases were also significantly increased according to smoking status and pack-years. Current smoking is associated with poor outcomes; even lower levels of exposure appear to be detrimental in HIV-infected veterans. These findings support the need for improvements in smoking cessation and for studies of mechanisms and diseases underlying increased mortality in smokers with HIV.