Epitranscriptomics: A New Layer of microRNA Regulation in Cancer.
Epitranscriptomics: A New Layer of microRNA Regulation in Cancer.
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Epitranscriptomics：癌症中microRNA调控的新层。
DOI：
10.3390/cancers13133372
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发表时间：
2021-07-05
期刊：
影响因子：
5.2
通讯作者：
Fulci V
中科院分区：
文献类型：
--
作者：
De Paolis V;Lorefice E;Orecchini E;Carissimi C;Laudadio I;Fulci V
MicroRNA是一种小的非编码RNA，作为基因表达的转录后调节因子。在过去的二十年中，它们在癌症中作为癌基因（oncomir）以及肿瘤抑制因子的作用已被广泛证实。近年来，研究RNA修饰的表观转录组学作为基因表达调控的一个新的研究领域，引起了人们极大的兴趣。几乎所有种类的真核RNA，包括miRNA，都经历了表转录组修饰。RNA修饰途径的改变已被描述为许多疾病，特别是在恶性肿瘤的背景下。本文就miRNAs的表观修饰与癌症之间的潜在联系作一综述。microRNA是后生动物中普遍存在的转录后水平基因表达调控因子，在多种生理和病理过程中发挥重要作用。因此，这些小的非编码RNA也参与癌症的发展和进展。此外，miRNA代表恶性肿瘤中有价值的诊断和预后生物标志物。在过去的二十年中，RNA修饰在多个水平上微调基因表达的作用已经被揭开。所有RNA种类都可能经历转录后修饰，统称为表位转录组修饰，在许多情况下，其影响RNA分子性质。在这方面，miRNA也不例外，并且它们已被证明经历几种转录后修饰。本文就miRNA的表位转录组修饰及其在肿瘤发生发展中的作用进行综述。
MicroRNAs are small non-coding RNAs, acting as post-transcriptional regulators of gene expression. In the last two decades, their role in cancer as oncogenes (oncomir), as well as tumor suppressors, has been extensively demonstrated. Recently, epitranscriptomics, namely the study of RNA modifications, has emerged as a new field of great interest, being an additional layer in the regulation of gene expression. Almost all classes of eukaryotic RNAs, including miRNAs, undergo epitranscriptomic modifications. Alterations of RNA modification pathways have been described for many diseases—in particular, in the context of malignancies. Here, we reviewed the current knowledge on the potential link between epitranscriptomic modifications of miRNAs and cancer. MicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer development and progression. Furthermore, miRNAs represent valuable diagnostic and prognostic biomarkers in malignancies. In the last twenty years, the role of RNA modifications in fine-tuning gene expressions at several levels has been unraveled. All RNA species may undergo post-transcriptional modifications, collectively referred to as epitranscriptomic modifications, which, in many instances, affect RNA molecule properties. miRNAs are not an exception, in this respect, and they have been shown to undergo several post-transcriptional modifications. In this review, we will summarize the recent findings concerning miRNA epitranscriptomic modifications, focusing on their potential role in cancer development and progression.
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影响因子：
4.5
作者：
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通讯作者：
Phizicky, EM
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影响因子：
4.1
作者：
Carissimi, Claudia;Laudadio, Ilaria;Fulci, Valerio
通讯作者：
Fulci, Valerio