Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing.
Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing.
复制标题
晶状体上皮源性生长因子 (LEDGF/p75) 和 p52 通过选择性剪接源自单个基因。
DOI：
10.1016/s0378-1119(99)00506-5
复制
发表时间：
2000
期刊：
影响因子：
3.5
通讯作者：
Shinohara,T
中科院分区：
文献类型：
--
作者：
Singh,DP;Kimura,A;ChylackJr,LT;Shinohara,T
A human gene that encodes lens epithelium-derived growth factor (LEDGF) was isolated, and the DNA sequence and the exon/intron organization was determined. The gene contains at least 15 exons and 14 introns and encodes LEDGF mRNA and p52 mRNA. Exons 1–15 encode LEDGF mRNA, and exons 1–9, and a part of the ninth intron encode a splice variant (p52). Sequences of the exon/intron junctions of the gene have the highly conserved GT/AG rule. Most intron/exon junctions correspond to junctions of individual protein motifs. Almost equal amounts of LEDGF and p52 are expressed in lens epithelial cells in culture. The LEDGF gene is assigned to chromosome 9p22.2, which is adjacent to the major cell malignancy locus.
代表血小板衍生生长因子 A 链的选择性剪接外显子的合成肽可调节正常人血清和多种生长因子刺激的有丝分裂发生。
DOI：
10.1016/s0021-9258(18)42542-2
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
L. Khachigian;C. Chesterman
通讯作者：
C. Chesterman
基因表达：信息的终结及其他
影响因子：
64.8
作者：
N. Proudfoot
通讯作者：
N. Proudfoot
选择性剪接的细胞周期蛋白 C mRNA 广泛表达、细胞周期调节，并编码截短的细胞周期蛋白盒。
DOI：
--
发表时间：
1996
期刊：
Oncogene.
影响因子：
--
作者：
Li,H;Lahti,JM;Kidd,VJ
通讯作者：
Kidd,VJ