ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens.
ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens.
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DOI：
10.2174/1566524013666131217112921
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发表时间：
2014-03
影响因子：
2.5
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Xu C;Wallace MB;Yang J;Jiang L;Zhai Q;Zhang Y;Hong C;Chen Y;Frank TS;Stauffer JA;Asbun HJ;Raimondo M;Woodward TA;Li Z;Guha S;Zheng L;Li M
Aberrant expression of a zinc transporter ZIP4 in pancreatic ductal adenocarcinoma (PDAC) has been shown to contribute to tumor progression and is a potential target for individualized therapy. The overall objective of this study was to determine whether ZIP4 could serve as a novel diagnostic and prognostic marker in human PDAC, and if it can be assessed by minimally invasive sampling using endoscopic ultrasound guided fine needle aspiration (EUS-FNA). Immunohistochemistry was performed to compare ZIP4 expression in the PDAC samples obtained from EUS-FNA and matched surgical tumors (parallel control). Samples were reported by sensitivity, specificity, and predictive values, all with 95% confidence intervals (CI). A total of 23 cases with both FNA and surgical specimens were evaluated. We found that ZIP4 was significantly over-expressed in tumor cells from both sets of samples. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ZIP4 for the diagnosis of PDAC were 72.9%, 72.5%, 76.1%, and 69.0% in EUS-FNA samples, and were 97.9%, 65.4%, 83.9%, and 94.4% in surgical specimens, respectively. The association between the positive rate of ZIP4 expression in FNA and surgical samples is statistically significant (P=0.0216). Both the intensity and percentage of ZIP4 positive cells from the surgical samples correlated significantly with tumor stage (P=0.0025 and P=0.0002). ZIP4 intensity level in FNA samples was significantly associated with tumor differentiation and patient survival. These results indicate that EUS-FNA is capable of non-operative detection of ZIP4, thus offering the potential to direct pre-operative detection and targeted therapy of PDAC.
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影响因子：
7.7
作者：
Varadarajulu, S;Tamhane, A;Eloubeidi, MA
通讯作者：
Eloubeidi, MA
DOI：
10.1073/pnas.0709307104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Li, Min;Zhang, Yuqing;Yao, Qizhi
通讯作者：
Yao, Qizhi
DOI：
10.1016/j.urolonc.2010.11.010
发表时间：
2012-11-01
影响因子：
2.7
作者：
Chen, Qi-guang;Zhang, Zhe;Kong, Chui-ze
通讯作者：
Kong, Chui-ze
ZIP4 是神经胶质瘤的新型分子标记。
影响因子：
15.9
作者：
Lin, Yi;Chen, Yong;Li, Min
通讯作者：
Li, Min
影响因子：
--
作者：
Chen, Da-Wei;Fan, Yao-Fu;Jiang, Xiao-Xiao
通讯作者：
Jiang, Xiao-Xiao