Addressing the challenges of cleft lip and palate research in India.
Addressing the challenges of cleft lip and palate research in India.
复制标题
DOI：
10.4103/0970-0358.57182
复制
发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Little J
中科院分区：
文献类型：
--
作者：
Mossey P;Little J
印度次大陆仍然是世界上人口最多的地区之一，估计仅印度就有11亿人口。估计每年有2 450万新生儿，每年有27 000至33 000例新生儿出现唇腭裂。在唇腭裂护理的获得和质量方面都存在不平等，城市与农村的获得存在明显差异，多年来，唇腭裂未修复的积累使其成为印度的一个重大卫生保健问题。近年来，通过SmileTrain和Transforming Faces Worldwide等非政府组织参与初次外科修复方案的干预，情况得到了显著改善。裂缝的原因是多因素的遗传和环境的输入和密集的研究工作取得了显着的进展，近年来在遗传领域的分子技术的促进。印度通过提高研究专门知识和拥有遗传、文化和社会经济多样性的人口，具有作出贡献的巨大潜力。2008年，世界卫生组织（世卫组织）认识到，包括出生缺陷在内的非传染性疾病导致婴儿死亡率和儿童发病率显著上升，并将唇腭裂纳入其全球疾病负担倡议。这将激发印度对出生缺陷登记的兴趣，以及旨在提高护理质量并最终预防非综合征性唇腭裂的国际努力。
The Indian sub-continent remains one of the most populous areas of the world with an estimated population of 1.1 billion in India alone. This yields an estimated 24.5 million births per year and the birth prevalence of clefts is somewhere between 27,000 and 33,000 clefts per year. Inequalities exist, both in access to and quality of cleft care with distinct differences in urban versus rural access and over the years the accumulation of unrepaired clefts of the lip and palate make this a significant health care problem in India. In recent years the situation has been significantly improved through the intervention of Non Governmental Organisations such as SmileTrain and Transforming Faces Worldwide participating in primary surgical repair programmes. The cause of clefts is multi factorial with both genetic and environmental input and intensive research efforts have yielded significant advances in recent years facilitated by molecular technologies in the genetic field. India has tremendous potential to contribute by virtue of improving research expertise and a population that has genetic, cultural and socio-economic diversity. In 2008, the World Health Organisation (WHO) has recognised that non-communicable diseases, including birth defects cause significant infant mortality and childhood morbidity and have included cleft lip and palate in their Global Burden of Disease (GBD) initiative. This will fuel the interest of India in birth defects registration and international efforts aimed at improving quality of care and ultimately prevention of non-syndromic clefts of the lip and palate.