Design of new questionnaires to measure quality of life and treatment satisfaction in hypothyroidism
Design of new questionnaires to measure quality of life and treatment satisfaction in hypothyroidism
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DOI：
10.1089/thy.2004.14.916
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发表时间：
2004-11-01
期刊：
影响因子：
6.6
通讯作者：
Weaver, JU
中科院分区：
文献类型：
--
作者：
McMillan, CV;Bradley, C;Weaver, JU
前言：本文报道了设计两种新的针对甲状腺功能减退症的疾病特异性问卷的工作：甲状腺功能低下依赖生活质量问卷（ThyDQoL）和甲状腺功能低下治疗满意度问卷（ThyTSQ）。方法：对30名女性和8名男性甲状腺功能减退患者（平均年龄51.9岁，范围29-79岁）进行半结构化访谈，探讨生活质量（QoL）和治疗经验，38名接受甲状腺素治疗的患者中有37名来自医院诊所和初级保健。结果：尽管接受了甲状腺素治疗，大多数受访者报告了甲状腺功能减退对生活质量的负面影响，特别是在精力、体能、动机、外表和体重方面。新设计的ThyDQoL有18个领域，涵盖了这些和其他受甲状腺功能减退影响的生活方面。这是一个个性化的措施，患者的感知，甲状腺功能减退对他们的生活质量的影响，其中考虑到个人适用的生活领域对患者的重要性。设计了对当前治疗满意度的7项测量（ThyTSQ-Present），但访谈也表明需要一个单独的4项部分来测量诊断前后对过去治疗的满意度（ThyTSQ-Past）。结论：ThyDQoL和ThyTSQ问卷对成人甲状腺功能减退患者具有良好的面效度和内容效度。它们现在已经准备好用于临床研究和心理测量评估。
Introduction: This paper reports work undertaken to design two new condition-specific questionnaires for use in hypothyroidism: the Underactive Thyroid-Dependent Quality of Life Questionnaire (ThyDQoL) and the Underactive Thyroid Treatment Satisfaction Questionnaire (ThyTSQ). Methods: Semistructured interviews exploring quality of life (QoL) and experiences of treatment were conducted with 30 women and 8 men with hypothyroidism, (mean age, 51.9; range, 29-79 years), 37 of 38 treated with thyroxine, recruited from hospital clinics and primary care. Results: Despite thyroxine treatment, most interviewees reported negative impact of hypothyroidism on QoL, particularly on energy, physical capabilities, motivation, physical appearance, and weight. The newly designed ThyDQoL has 18 domains covering these and other aspects of life affected by hypothyroidism. It is an individualized measure of patients' perceived,impact of hypothyroidism on their QOL, which takes into account the importance of personally applicable life domains to the patient. A 7-item measure of satisfaction with current treatment was designed (ThyTSQ-Present) but interviews also indicated the need for a separate 4-item section measuring satisfaction with past treatment around the time of diagnosis (ThyTSQ-Past). Conclusions: The ThyDQoL and ThyTSQ questionnaires have good face validity and content validity for adults with hypothyroidism. They are now ready for use in clinical research and psychometric evaluation.