Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats
Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats
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DOI：
10.1016/s0741-8329(00)00144-0
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发表时间：
2001-02-01
期刊：
影响因子：
2.3
通讯作者：
Colombo, G
中科院分区：
文献类型：
--
作者：
Agabio, R;Carai, MAM;Colombo, G
本研究旨在评估低剂量乙醇对选择性饲养的撒丁岛酒精偏好（sP）和撒丁岛酒精非偏好（sNP）大鼠运动活性的影响。以0、0.25和0.5g/kg（i. p.）即将大鼠暴露于开放的领域竞技场15分钟。的数量，作为运动活动的指数，在盐水处理的sP比盐水处理的sNP大鼠显着降低，提示在sP比sNP大鼠的遗传决定的更高的情绪状态。乙醇给药导致sP大鼠的方形交叉数量呈剂量依赖性显着增加，而对sNP大鼠完全无效。这些结果提示sP/sNP大鼠系乙醇偏好与乙醇诱导的运动刺激之间存在正相关。(C)2001 Elsevier Science Inc. All rights reserved.
The present study was conducted to evaluate the effect of low doses of ethanol on motor activity in selectively bred Sardinian alcohol-preferring (sP) and Sardinian alcohol-nonpreferring (sNP) rats. Ethanol was acutely administered at the doses of 0, 0.25, and 0.5 g/kg (i.p.) immediately before rat exposure to an open-field arena for 15 min. The number of square crossings, used as index of motor activity, was significantly lower in saline-treated sP than in saline-treated sNP rats, suggestive of a genetically determined higher emotional state in sP than in sNP rats. Ethanol administration resulted in a dose-dependent, significant increase in the number of square crossings in sP rats, whereas it was completely ineffective in sNP rats. These results suggest to us that a positive relationship exists between ethanol preference and ethanol-induced motor stimulation in sP/sNP rat lines. (C) 2001 Elsevier Science Inc. All rights reserved.