Coxiella subversion of intracellular host signaling.
Coxiella subversion of intracellular host signaling.
复制标题
柯克斯体破坏细胞内宿主信号传导。
DOI：
10.1007/978-94-007-4315-1_7
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发表时间：
2012
影响因子：
--
通讯作者：
Voth,DanielE
中科院分区：
文献类型：
--
作者：
Hussain,SKauser;Voth,DanielE
Coxiella burnetiiis a highly infectious bacterial pathogen that replicates in a specialized vacuole inside eukaryotic cells. Due to a prolonged growth cycle,Coxiellacontinuously manipulates cellular processes to generate this parasitophorous vacuole (PV) and promote host cell viability. Here, we discuss recent findings that indicateCoxiellamodulates several host signaling pathways to influence survival and ensure intracellular replication. The pathogen actively inhibits apoptotic cell death and activates the pro-survival kinases Akt and Erk1/2 to promote host viability.Coxiella’s anti-apoptotic activity also involves the interface between autophagy and apoptosis, which is regulated by the interaction of autophagy-related Beclin-1 and anti-apoptotic Bcl-2. Additionally,Coxiellarequires host kinase activity for PV biogenesis and maintenance. Thus, signaling modulation byCoxiellais critical for multiple aspects of host cell parasitism. Collectively, recent signaling studies have enhanced our understanding of the uniqueCoxiella-host cell interaction. Identification of bacterial factors that regulate signaling events will further our ability to model this intriguing infectious process.
