Mammalian facilitative glucose transporter family: structure and molecular regulation.
Mammalian facilitative glucose transporter family: structure and molecular regulation.
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DOI：
10.1146/annurev.ph.54.030192.004403
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发表时间：
1992
影响因子：
18.2
通讯作者：
J. Pessin;G. Bell
中科院分区：
文献类型：
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作者：
J. Pessin;G. Bell
除了从小肠腔和肾近端小管主动摄取葡萄糖外，“葡萄糖跨细胞膜转运”是通过易化扩散发生的。目前，编码具有易化葡萄糖转运蛋白特性的五种结构相关蛋白的 cDNA 已被分离和表征（表 I）。这五种亚型已被命名为 GLUT 红细胞、GLUT2/肝、GLUT3/脑、 GLUT4/肌肉脂肪和 GLUT5/小肠 (25,52) 除了这五种功能性促进葡萄糖转运蛋白外，还在人体组织中鉴定了一种表达的促进葡萄糖转运蛋白假基因样序列 (GLUT6)。该序列是普遍表达的 mRNA 的一部分，但不编码功能性蛋白质。为分离人和大鼠GLUT 1提供了基础
Except for the active uptake of glucose from the lumen of the small intestine and proximal tubule of the kidney, the" transport of glucose across cell membranes' occurs by facilitated diffusion. Currently, cDNAs encoding five structurally-related proteins with the properties of faCilitative glucose transporters have been isolated and characterized (Table I). The five isoforms have been designated GLUT lIerythrocyte , GLUT2/liver, GLUT3/brain, GLUT4/muscle-fat, and GLUT5/smali intestine (25,52). In addition to these five functional facilitative glucose transporters, an expressed facilitative glu cose transporter pseudogene-like sequence (GLUT6) has been identified in human tissues (39). This sequence is part of a ubiquitously expressed mRNA, but does not encode a functional protein. The purification and characteriZation of the human erythrocyte glucose transporter provided the basiS" for th"e isolation of human and rat GLUT 1